Facebook Pixel"Obligatory" consumption of probiotics as a strategy to enhance general health
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"Obligatory" consumption of probiotics as a strategy to enhance general health

"Obligatory" consumption of probiotics as a strategy to enhance general health

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By Juran K. on Nov 04, 2020

[1] https://www.nature.com/articles/nrgastro.2017.20

[2] https://www.theguardian.com/lifeandstyle/2018/mar/19/is-your-gut-keeping-you-awake-at-night

[3] https://www.theguardian.com/society/2013/sep/05/bacteria-slim-treat-obesity-study

[4] https://www.theguardian.com/science/2013/mar/31/bacteria-faecal-transplant-gut-mary-roach-gulp

[5] https://advances.sciencemag.org/content/4/2/eaao4502

[6] https://openmicrobiologyjournal.com/VOLUME/14/PAGE/1/

[7] https://www.sciencedaily.com/releases/2017/06/170601151924.htm

Creative contributions

Categorise diet patterns, geographical and ethnic groups before administering

[1] A.B. MothersheadDining customs around the world Garrett Park Press, Maryland (1982), p. 150

[2] A.B. MothersheadDining customs around the world Garrett Park Press, Maryland (1982), p. 150

[3] Gupta VK, Paul S, Dutta C. Geography, Ethnicity or Subsistence-Specific Variations in Human Microbiome Composition and Diversity. Front Microbiol. 2017;8:1162. Published 2017 Jun 23. doi:10.3389/fmicb.2017.01162

by Subash Chapagain on Nov 05, 2020

Juran K. 21 days ago
Subash ChapagainThank you for your contribution!

I completely agree. The categorization you mentioned is of incredible importance and would be the first step in this process.

I didn´t know about countries' variabilities in the microbiome being this big. It would be nice to see if this correlates with climate, diet, ethnicity, and cluster people in specific groups. Good point!

I was just thinking, what if, for e.g., some people live longer because they have better gut microbiota? Wouldn´t it be good to change the microbiota of other people to something more similar to the long-living ones?
Shubhankar Kulkarni 20 days ago
Juran K. You are right. There do exist significant differences in the gut microbiota of the long-lived people when compared to controls. There also exists a difference across geographical regions and countries. One study observed a common link across long-lived people from different regions. Their comparative analysis showed that there is higher biodiversity within the Ruminococcaceae family in centenarians, compared to younger adults, irrespective of their nationality. Bacterial signatures were common among extremely old people of different nationalities. They identified Akkermansia, Alistipes, and Ruminococcoaceae D16 as signature taxa of long-lived people. Their results also suggested a change in the gut ecology during extreme aging from their younger counterparts. That change may be one of the keys to a long life.

Reference: I strongly encourage you to look at figures 2 and 3 from the study report. https://www.sciencedirect.com/science/article/abs/pii/S0047637418302057
Juran K. 20 days ago
Shubhankar Kulkarni This could be a way to extract a new "healthy aging" checkpoint - biochemical changes and processes related to the specific microbiota activity in the gut of centenarians.

Extensive quality control and risk-benefit ratio are major restrictions in generalization of probiotics

[1] de Simone C. The Unregulated Probiotic Market. Clin Gastroenterol Hepatol. 2019 Apr;17(5):809-817. doi: 10.1016/j.cgh.2018.01.018. Epub 2018 Mar 14. PMID: 29378309.

[2] Sanders ME, Akkermans LM, Haller D, Hammerman C, Heimbach J, Hörmannsperger G, Huys G, Levy DD, Lutgendorff F, Mack D, Phothirath P, Solano-Aguilar G, Vaughan E. Safety assessment of probiotics for human use. Gut Microbes. 2010 May-Jun;1(3):164-85. doi: 10.4161/gmic.1.3.12127. Epub 2010 Mar 4. PMID: 21327023; PMCID: PMC3023597.

by Kritika Bansal on Nov 11, 2020

Juran K. 14 days ago
I completely agree.
Also, no study, proof, or law will erase the general fear that the term bacteria causes.

What I thought is that maybe an invisible dose - an almost insignificant amount of known beneficial bacteria could be a good entry point to "start the wave" and also have a hormetic effect. But the amount must be so small that even if someone eats/drinks 10x the recommended dose, nothing bad happens.
So finding a dose below all reported doses that caused adverse effects and implementing it in the strategical market solution.
What do you think about that?

Will the "obligation" work?

by Shubhankar Kulkarni on Nov 05, 2020

Juran K. 21 days ago
Good point! Although in very specific places, you can still buy non-iodized salt in some shops. That could be a nice strategy - to leave the decision to people. Give them scientific data about probiotic benefits and let them choose in the market.

What about people allergic to certain foods?

by Shubhankar Kulkarni on Nov 05, 2020

Juran K. 21 days ago
I would first look at how current probiotic products dealt with this issue. The products would consist of small doses of probiotics that are beneficial to the whole population, or would, as cat/dog food, be categorized according to the age.

If an individual is intolerant, then it could use chocolate bars, flour, or something not-diary, but still enriched with probiotics.

Although I see many beneficial effects of this idea, I must agree your last paragraph is of my biggest concern. Analyzing the individual´s stool and then tailoring the personalized probiotic could be a better way.

Probiotic foods with specific bacteria

by Shubhankar Kulkarni on Nov 18, 2020

Juran K. 7 days ago
The idea could work, but if it will be vending machines or dispensers doing that, it would be even less probable that people will trust these products. Food in vending machines sometimes stays for few weeks until someone buys it. Plus, the system should be sterile as a lab. Therefore, I would rather propose the "probiotic machines" in certain pharmacies, where the process can be monitored and where people would trust the product more.
Shubhankar Kulkarni 6 days ago
Juran K. Agreed! Such machines in pharmaceutical stores would be more trusted. However, I think that limits sales. More people visit grocery stores than the pharmacy. And since the idea is to make probiotic foods, would it be better to have the products in the grocery store? I would like to know your opinion on the second paragraph in my suggestion. It is a more feasible idea than the vending-machine one. Also, the idea eliminates all the problems with generalizing the probiotic constituents in the foods. People can then buy the probiotics (microbes) that they need at their age, geographical location, race, sex, etc. They can buy multiple products based on the prescriptions given by their physicians.
Juran K. 5 days ago
Shubhankar Kulkarni I agree with the limitation of the sales you mentioned. Grocery stores would be the best.

Concerning the second paragraph, that is exactly what we need. From the start, there would be only a few options available, but with more research being done, new, more specific products could emerge., at the end resulting in all varieties of probiotic yogurts available (based on your specific needs). It could be done with other everyday products such as coffee milk, coconut and almond milk, smoothies, protein bars, etc. But, in my opinion, it should only be available on prescription, at least at the beginning.

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