A growing list of top biotech startup ideas
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By Darko Savic on Aug 19, 2020
Cure for allergies by eliminating the memory cells that produce the antibodies
Figure out a way to single out and eliminate the memory lymphocytes that produce the antibodies to specific allergens. Figure out a way to prevent the formation of new allergen-specific lymphocytes for the duration of the therapy. By doing so hopefully rid the body of allergy.
by Darko Savic on Aug 19, 2020
Gene therapies to remove latent viruses
Here is a way to target Herpes simplex 1 virus https://www.nature.com/articles/s41467-020-17936-5 There are many other persistent viruses that could be targeted with similar methods
by Darko Savic on Aug 19, 2020
Cell Cleansing Therapy
Find a way to clear neurotoxic protein aggregates and prevent the build-up of plaque with a cell cleansing therapy, maybe methods that can stimulate junk removal processes could be used for this.
by Jamila Ahmed on Aug 20, 2020
Self-replicating biodegradable utensils (growing spoons)
What if plants could be engineered to grow parts with useful shapes looking like spoons, cups, take-away food packaging. These would then be harvested as-is, with minimal processing necessary and supplied as products to the eco-friendly food industry. Alternatively this could also be done with cell cultures grown in specifically shaped moulds. But this would add more work to the process which is not idea. Spoons growing on trees would be amazing.
by Dragan Otasevic on Aug 21, 2020
Mouth microbiota modification therapy to protect your teeth better than tooth paste
A 2 component product: 1. Eradicate the existing oral pathogen species with matching bacteriophage viruses. (mouthwash) 2. Inoculate the mouth with beneficial bacteria (chewable tabs) that have been engineered to kill and outcompete the pathogen species. This has been described here: https://brainstorming.com/r/i7
by Darko Savic on Aug 21, 2020
Fully automated and autonomous mouse lab
Develop a fully automated and autonomous mouse lab that can hold several mice (different sized models). The lab should be self-sufficient (food, water, cleaning, automated therapies) for the life duration of mice. Place and forget, monitor progress via webcams, and sensors. This would be supplied to research labs.
by Dragan Otasevic on Aug 22, 2020
Finding a way to induce suspended animation in humans
Observe the animal models of suspended animation (diapause, torpor, and hibernation) to find out the specific mechanisms involved and find out whether such a good thing could be activated in humans!
by Jamila Ahmed on Aug 24, 2020
MedicSmartPhones as Next generation Point of care testing Devices
In this new decade, time and patience are the most significant assets upon which business ideas can thrive. Imagine a smartphone with integrated multiple sensors for different diseases, all being non-invasive, which could detect your temperature, kidney function, diabetes. It can be the next significant change in the biomedical and Smartphone industries. With the rise in well-published, authenticated, clinically proven researches in various fields of diagnosis using nanotechnology, its high time that we focus on integrating those non-invasive biosensors with state of the art UI. There are about 870 plus biomarkers alone for volatile organic compounds produced in the blood for various metabolic changes, DOI: 10.1088/1752-7155/8/1/014001 with acetone-based biosensors are considered the best for Diabetes monitoring. Thus using integrated nanosensors on a smartphone would solve the problems for live tracking in hospitals. Recorded data can be shared easily to Healthcare providers who can respond; accordingly, earlier detection of any disease increases survival rate.
by Arvind kumar sharma on Aug 27, 2020
One protocol to rule them all
Molecular-based techniques have the advantage of identifying direct a microorganism according to his gene characteristics as the size of the nucleic acid sequence. In general, a polymerase chain reaction is a method of amplifying a sequence of DNA or RNA using specific primers. Moreover, the resulting products may be further separated with the aid of electrophoresis techniques. Companies have a great diversity of protocols and methods to conduct PCR analysis with different mechanisms, protocols, and apparatus. An open-source library with a unique protocol to conduct PCR analysis with the same reagents which suit o every PCR device and laboratory would be of great interest. This protocol aim at simplifying the usage of this molecular tool, PCR
by christos stefanis on Aug 29, 2020
Plant tissue culture kits for growing medicinal, nutraceutical, and endangered plants at home
Plant tissue culture (PTC) is a biotechnological technique that allows for the mass propagation, cloning, and genetic modification of plants. It can also be used to produce primary and secondary metabolites from isolated cell lines or callus, an amorphous cell mass in some way similar to a tumor. The donor tissue, called explant, is taken from a living plant, disinfected, and then transferred to an artificial growth medium under sterile conditions. If the explant receives the right stimuli, its cells will divide and spread over the medium, forming the already mentioned callus. The latter can now be treated with certain plant growth regulators (PGR) and so-called elicitors in order to produce secondary metabolites. Alternatively, whole plants can be produced by inducing organogenesis or somatic embryogenesis. While these processes require certain lab equipment and scientific knowledge, once established, the cultures could be maintained at home by anyone. Thus, people could buy the PTC kit and either use the compounds produced by the cultures or transfer in vitro grown plantlets to non-sterile soil conditions, in order to grow whole plants with known genotypic and phenotypic characteristics. With regard to endangered species, private households could contribute to their preservation by growing them at home. https://www.pagepress.org/journals/index.php/pb/article/view/8385
by Felix Krengel on Aug 29, 2020
Apply Bacteria to the Scalp for Hair Regeneration
Find out if there are any bacteria that promote hair regeneration. Then select these beneficial species for a cream that can be applied to your scalp for hair growth. I've written it in more detail here: https://brainstorming.com/ideas/apply-bacteria-to-the-scalp-for-hair-regeneration/21
by Jamila Ahmed on Aug 31, 2020
Microbial strain bank for antibiotic producing microbes
South Asian geography, especially the Himalayan region is profoundly rich in its microbial ecology where the cryosphere is heavily loaded with many microorganisms that have a high biotechnological potential in terms of antimicrobial and bioactive metabolites production . Many microbial and fungal species like Actinomycetes and Streptomycetes can be sampled and sourced from the various geographic locations in the whole region. After primary screening for antibiotic production , the promising candidates can then be preserved and stored at the Microbial Strain Bank. Once the repository becomes large enough, these candidates can be further studied for optimal antibiotic production and then after confirming through secondary screening, conventional genetic engineering tools can be applied for industrial production of the target antibiotics. Since the natural environment has infinite genetic variants of these microbes, we can even develop models using AI and then specifically target locations with a higher probability of finding a better antibiotic producer. Once started, the idea can be extended from antibiotic production to other applications like bio-fertilizers and enzyme production as well. About microbial strain banks: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241729/ References: 1. Dhakar, K., & Pandey, A. (2020). Microbial Ecology from the Himalayan Cryosphere Perspective. Microorganisms, 8(2), 257. https://doi.org/10.3390/microorganisms8020257 2.Sapkota, A., Thapa, A., Budhathoki, A., Sainju, M., Shrestha, P., & Aryal, S. (2020). Isolation, Characterization, and Screening of Antimicrobial-Producing Actinomycetes from Soil Samples. International journal of microbiology, 2020, 2716584. https://doi.org/10.1155/2020/2716584
by Subash Chapagain on Sep 02, 2020
Sugar plastic. Ethanol biodegradable polymer
by Daniel - on Sep 02, 2020
Upcycle organic waste into food supplements
Organic waste (including food waste) is usually rich in fundamental nutrients like proteins (e.g. spent oilseeds) amino acids, carbohydrates and such. An ideal combination of biotechnology (using genetically engineered microbes) and food processing techniques to extract or upcycle these nutrients into food supplements such as protein supplements or energy supplements can positively address multiple challenges - 1. Move closer to zero waste and circular economy 2. Address malnutrition (PEM) and by extension enable growth in the lowest socio-economic strata Some of the steps in this direction have been taken by startups such as: 1. REGRAINED - Spent grain (after making beer) to bread and protein bars 2. PLANETARIANS - Spent sunflower oilseed into high protein chips A dream black-box would be a small (maybe suitcase sized) unit that would be able to upcycle any organic waste into usable food supplement. Some interesting work in the area may be found on the following link: https://www.fastcompany.com/90337075/inside-the-booming-business-of-fighting-food-waste
by Loukik Arora on Sep 12, 2020
A DIY phytochemical (essential oil) extraction kit
With time, the number of people that are seeking to grow their own herbs and medicinal plants is increasing. From peppermints to rosemary and basils, these easy to grow plants are rich in a lot of phytochemical compounds and essential oils like flavonoids and terpenoids, and antioxidants as well. However, to get the full benefit of these natural reservoirs of medicinally important compounds, we need some precisely formulated mixture of solvents and chemicals, assisted by a series of physical/mechanical processes for the oil extraction. Hence, one promising start-up would be to sell easy-to-do phytochemical extraction kits that would enable the herb growers to prepare their own crude extracts of essential oils. The kit can contain the following different components: 1. Crusher/ grinder- for making fine powder of the plant parts like flowers and leaves 2. Distillation apparatus- for steam distillation to boil the plants until the essential oils separate from the plant and float on water. The oil can be later collected and stored separately in an amber or glass bottle. 3. Different kinds of solvents- for separating heat labile oils, solvent extraction is the best way that allows us to do phase separation of the immiscible oils (example of such solvents are methanol and ethanol) 4. Filtration apparatus- for preparing the final usable product and ensure maximum purity of the crude extract Supplemented with how-to guide, this biotech product can prove beneficial for extracting oils from our own herb garden. It holds the possibility of saving thousands of rupees, all the while engaging the growers into a meaningful scientific experience.
by Subash Chapagain on Sep 19, 2020