Facebook PixelA list of brain junk substances that build up with age
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A list of brain junk substances that build up with age

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Darko Savic
Darko Savic Nov 24, 2020
9
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Tau protein

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Subash Chapagain
Subash Chapagain Nov 24, 2020

[1]https://www.sciencedirect.com/topics/neuroscience/tau-protein

[2]https://www.nature.com/articles/s41593-020-00728-x#:~:text=Alzheimer's%20disease%20(AD)%20is%20characterized,neurons%2C%20neurodegeneration%20and%20memory%20loss.&text=These%20results%20are%20important%20for,of%20astrocytes%20in%20hippocampal%20function.

Dysfunctional mitochondria

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Shubhankar Kulkarni
Shubhankar Kulkarni Nov 24, 2020

[1]Mattson MP, Arumugam TV. Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States. Cell Metab. 2018;27(6):1176-1199. doi:10.1016/j.cmet.2018.05.011

[2]Lin DT, Wu J, Holstein D, Upadhyay G, Rourk W, Muller E, Lechleiter JD. Ca2+ signaling, mitochondria and sensitivity to oxidative stress in aging astrocytes. Neurobiol Aging. 2007 Jan;28(1):99-111. doi: 10.1016/j.neurobiolaging.2005.11.004. Epub 2005 Dec 15. PMID: 16359757.

[3]Ghosh D, LeVault KR, Barnett AJ, Brewer GJ. A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neurons. J Neurosci. 2012 Apr 25;32(17):5821-32. doi: 10.1523/JNEUROSCI.6192-11.2012. PMID: 22539844; PMCID: PMC3376759.

Damaged oxidants

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Shubhankar Kulkarni
Shubhankar Kulkarni Nov 24, 2020

[1]Mattson MP, Arumugam TV. Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States. Cell Metab. 2018;27(6):1176-1199. doi:10.1016/j.cmet.2018.05.011

Iron (Fe) accumulation

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Subash Chapagain
Subash Chapagain Nov 24, 2020

[1]https://link.springer.com/chapter/10.1007/978-3-7091-9322-8_2

[2]Doorn, J.M., Kruer, M.C. Newly Characterized Forms of Neurodegeneration with Brain Iron Accumulation. Curr Neurol Neurosci Rep 13, 413 (2013). https://doi.org/10.1007/s11910-013-0413-9

Ceramide

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Shubhankar Kulkarni
Shubhankar Kulkarni Nov 25, 2020

[1]Appleton JP, Scutt P, Sprigg N, Bath PM. Hypercholesterolaemia and vascular dementia. Clin Sci (Lond). 2017 Jun 30;131(14):1561-1578. doi: 10.1042/CS20160382. PMID: 28667059.

[2]Cutler RG, Kelly J, Storie K, Pedersen WA, Tammara A, Hatanpaa K, Troncoso JC, Mattson MP. Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2070-5. doi: 10.1073/pnas.0305799101. Epub 2004 Feb 15. PMID: 14970312; PMCID: PMC357053.

[3]Shimabukuro MK, Langhi LG, Cordeiro I, Brito JM, Batista CM, Mattson MP, Mello Coelho Vd. Lipid-laden cells differentially distributed in the aging brain are functionally active and correspond to distinct phenotypes. Sci Rep. 2016 Mar 31;6:23795. doi: 10.1038/srep23795. PMID: 27029648; PMCID: PMC4814830.

Neurotoxic forms of α-synuclein

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Shubhankar Kulkarni
Shubhankar Kulkarni Nov 25, 2020

[1]Mattson MP, Arumugam TV. Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States. Cell Metab. 2018;27(6):1176-1199. doi:10.1016/j.cmet.2018.05.011

TDP-43

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Jamila
Jamila Nov 25, 2020

[1]Zhang, Lumi, et al. "TDP-43 and Limbic-Predominant Age-Related TDP-43 Encephalopathy." Frontiers in Aging Neuroscience 11 (2020): 376.

[2]Wilson, Robert S., et al. "TDP-43 pathology, cognitive decline, and dementia in old age." JAMA neurology 70.11 (2013): 1418-1424.

Lipofuscin

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Shubhankar Kulkarni
Shubhankar Kulkarni Nov 24, 2020

Amyloid beta

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Darko Savic
Darko Savic Nov 24, 2020

[1]Soto C, Estrada L. Amyloid inhibitors and beta-sheet breakers. Subcell Biochem. 2005;38:351-64. doi: 10.1007/0-387-23226-5_18. PMID: 15709488.

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General comments

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Darko Savic
Darko Savic2 months ago
Here are two cool sessions that focus on junk clearance:
https://brainstorming.com/r/s19
https://brainstorming.com/r/s33