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Brainstorming
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Brainstorming session

Antibiotic resistance: what can we do about it?

Antibiotic resistance: what can we do about it?

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By Nitish Sharma on Oct 26, 2020

[1] Allen, H., Donato, J., Wang, H. et al. Call of the wild: antibiotic resistance genes in natural environments. Nat Rev Microbiol 8, 251–259 (2010). https://doi.org/10.1038/nrmicro2312

Creative contributions

Find new ways to destroy pathogenic bacteria - namely CRISPR.

[1] Chokshi, Aastha, et al. "Global contributors to antibiotic resistance." Journal of global infectious diseases 11.1 (2019): 36.

[2] Terns, Michael P., and Rebecca M. Terns. "CRISPR-based adaptive immune systems." Current opinion in microbiology 14.3 (2011): 321-327.

[3] Langdon, Amy, Nathan Crook, and Gautam Dantas. "The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation." Genome medicine 8.1 (2016): 39.

[4] Khan, Rabia, Fernanda Cristina Petersen, and Sudhanshu Shekhar. "Commensal bacteria: an emerging player in defense against respiratory pathogens." Frontiers in Immunology 10 (2019): 1203.

[5] Askarova, Sholpan, et al. "The Links Between the Gut Microbiome, Aging, Modern Lifestyle and Alzheimer's Disease." Frontiers in Cellular and Infection Microbiology 10 (2020): 104.

by Jamila on Oct 26, 2020

Nitish Sharma a month ago
I think the idea to find novel antibiotics against the resistant pathogen is very much abstract and does not seem to be that much reliable. Because once a pathogen develops resistance against a particular drug it certainly develops for others in a quicker way For eg. we have multi drug-resistant Staph aureus etc. CRISPR-Cas system is a promising tool but it has its own disadwantages and public prespectives and perceptions. We exactly dont know when we will be able to use this tool in public health. Therefore, for now, we dont have any method and technique on the ground to fighjt this virtual pandemic.

More responsible doctor's prescriptions

[1] T. P. Lam and K. F. Lam, “What are the non-biomedical reasons which make family doctors over-prescribe antibiotics for upper respiratory tract infection in a mixed private/public Asian setting?,” J. Clin. Pharm. Ther., 2003.

[2] “Race against time to develop new antibiotics,” Bull. World Health Organ., 2011.

by Martina Pesce on Oct 26, 2020

Nitish Sharma a month ago
A philosophical solution though. The practicality of which is certainly not accountable.
Shubhankar Kulkarni a month ago
Martina Pesce I agree that doctors should prescribe antibiotics responsibly. There exist standard protocols (might differ from country to country) for the administration of antibiotics. [1,2] However, the decision of prescription of the antibiotics lies with the physicians. I don't think there exists enforcement of these rules, at least for those pertaining to prescribing antibiotics. Complex procedures and surgeries might have rules enforced strictly. From the physician's point of view, the symptoms vary largely from patient to patient. A "one rule fits all" strategy does not work. I don't know how we can come up with a solution that respects both views.

References:
1. https://www.nice.org.uk/about/what-we-do/our-programmes/nice-guidance/antimicrobial-prescribing-guidelines
2. http://iamrsn.icmr.org.in/images/pdf/STG270217.pdf

Implementing "natural antibiotics" in our diet

[1] https://www.medicalnewstoday.com/articles/321108#seven-best-natural-antibiotics

[2] https://www.medlife.com/blog/12-best-natural-antibiotics-infection/#4-red-pepper

by Juran K. on Oct 28, 2020

Blocking the bacterial "evolvability factors"

[1] https://www.sciencedaily.com/releases/2018/11/181116164514.htm

by Shubhankar Kulkarni on Nov 02, 2020

Take antibiotics only when absolutely necessary

by Shubhankar Kulkarni on Oct 26, 2020

Do not miss your antibiotic doses

by Shubhankar Kulkarni on Oct 26, 2020

Darko Savic a month ago
And finish the entire course as prescribed. Often that means continuing to take the antibiotics past the time where you feel well again. Any microbes that manage to survive are the ones most likely to evolve antibiotic resistance. So finish them off properly while you have the upper hand.

Hospitals should strictly comply with the cleaning and safety procedures

by Shubhankar Kulkarni on Oct 26, 2020

Povilas S a month ago
I've heard about a study which showed that only 1/3 of the doctors (as far as I remember) wash their hands before and after entering the hospital room (I think it was the operating room or maybe a room where they inspect patients, etc.). And it didn't change even after they installed cameras and put signs about this:D

Strictly avoid using expired antibiotics

by Shubhankar Kulkarni on Oct 26, 2020

Proper disposal of expired antibiotics

by Shubhankar Kulkarni on Oct 26, 2020

Try to prevent infections in the first place

by Jamila on Oct 26, 2020

Antibiotics resistance is not necessarily being spread by taking these drugs directly

by Nitish Sharma on Oct 28, 2020

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