ByApoorva Kulkarni
How can we overcome the problem of resistance of the senescent cells to senolytics?
Sep 25, 2020
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Brainstorming sessionAohona Datta Aug 20, 2020
Shubhankar Kulkarni Aug 21, 2020
Can hormesis slow down senescence by altering DNA methylation fingerprint?
AD
[1]Pan, Yong et al. “Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling.” Cell metabolism vol. 13, 2011, p. 668-78
[2]Calabrese, Edward J, and Mark P. Mattson. “How Does Hormesis Impact Biology, Toxicology, and Medicine?” Npj Aging and Mechanisms of Disease 3, 2017, p. 13.
[3]Levine, Morgan E., et al. “A DNA Methylation Fingerprint of Cellular Senescence.” BioRxiv, Jan. 2019, p. 674580.
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Creative contributions
Hormesis vs. Time
JK
Anti-aging effects of hormesis-induced epigenetic alterations