Brainstorming session
Can Viral Resistance Be Engineered in Humans?
Image credit: Fusionanimation.co.uk / unsplash
By Jamila Ahmed on Jul 27, 2020
[1] Saha, Shreya, and Kristiina Mäkinen. "Insights into the Functions of eIF4E-Biding Motif of VPg in Potato Virus A Infection." Viruses, 12.2, 2020, pp. 197.
[2] Ruffel, Sandrine, et al. "A natural recessive resistance gene against potato virus Y in pepper corresponds to the eukaryotic initiation factor 4E (eIF4E)." The Plant Journal, 32.6, 2002, pp. 1067-1075.
[3] Montero, Hilda, Rebeca García-Román, and Silvia I. Mora. "eIF4E as a control target for viruses." Viruses, 7.2, 2015, pp. 739-750.
[4] Lellis, Andrew D., et al. "Loss-of-susceptibility mutants of Arabidopsis thaliana reveal an essential role for eIF (iso) 4E during potyvirus infection." Current Biology, 12.12, 2002, pp. 1046-1051.
Creative contributions
Synthetic Genome Recoding
by Darko Savic on Aug 04, 2020
CRISPPR/Cas9 editing of host cells for viral resistance
by Subash Chapagain on Sep 14, 2020
I wonder how long it would take for the first virus to appear for the recoded organism...
I think laboratory versions are already there. CpG recoding is indeed a brilliant approach. If all hell doesn't break lose for me, this is going to be my PhD research topic, possibly starting in 2021. ...
This is great!!...