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Can we reverse greying of the hair?

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Jamila
Jamila Aug 28, 2020

[1]Seiberg, M. "Age‐induced hair greying–the multiple effects of oxidative stress." International journal of cosmetic science 35.6 (2013): 532-538.

[2]Kumar, Anagha Bangalore, Huma Shamim, and Umashankar Nagaraju. "Premature graying of hair: review with updates." International journal of trichology 10.5 (2018): 198.

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Stem cell based therapies for hair regeneration

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Subash Chapagain
Subash Chapagain Sep 09, 2020
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Jamila
Jamila 4 months ago
Exosomes/miRNA definitely have a big role in melanin production. In a recent study, researchers found that miRNA secreted by keratinocyte derived exosomes had a role in regulating melanogenesis. Specifically, miR-330-5p was produced by keratinocyte derived exosomes. The exosomes with increased expression of miR-330-5p caused an increase in miR-330-5p in melanocytes which resulted in reduced melanin production. (https://www.sciencedirect.com/science/article/pii/S0923181119300271) On the other hand, you have miR-379 which promotes pigmentation. miR‐379 is highly expressed in alpaca melanocytes which leads to increased melanogenesis and proliferation by targeting the insulin‐like growth factor 1 receptor. (https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.14095) These are just examples of how miRNA can positively or negatively impact pigmentation.

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Jamila
Jamila Aug 28, 2020

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Jamila
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