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Can we target the immune cells to ameliorate the ageing phenotype?

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Antonio Carusillo
Antonio Carusillo Dec 03, 2020

[1]Aiello Anna, Farzaneh Farzin, Candore Giuseppina, Caruso Calogero, Davinelli Sergio, Gambino Caterina Maria, Ligotti Mattia Emanuela, Zareian Nahid, Accardi Giulia; Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention Frontiers in Immunology, vol. 10 2019 DOI=10.3389/fimmu.2019.02247

[2]De la Fuente M. (2014) The Immune System, a Marker and Modulator of the Rate of Aging. In: Massoud A., Rezaei N. (eds) Immunology of Aging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39495-9_2

[3]Glyn Nelson, Olena Kucheryavenko, James Wordsworth, Thomas von Zglinicki, The senescent bystander effect is caused by ROS-activated NF-κB signalling, Mechanisms of Ageing and Development, Volume 170, 2018, Pages 30-36, ISSN 0047-6374, https://doi.org/10.1016/j.mad.2017.08.005.

[4]De la Fuente M. (2018) Oxidation and Inflammation in the Immune and Nervous Systems, a Link Between Aging and Anxiety. In: Fulop T., Franceschi C., Hirokawa K., Pawelec G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-64597-1_115-1

[5]Lingappan K. NF-κB in Oxidative Stress. Curr Opin Toxicol. 2018;7:81-86. doi:10.1016/j.cotox.2017.11.002

[6]De la Fuente M, Miquel J. An update of the oxidation-inflammation theory of aging: the involvement of the immune system in oxi-inflamm-aging. Curr Pharm Des. 2009;15(26):3003-26. doi: 10.2174/138161209789058110. PMID: 19754376.

[7]Moreno-García A, Kun A, Calero O, Medina M, Calero M. An Overview of the Role of Lipofuscin in Age-Related Neurodegeneration. Front Neurosci. 2018;12:464. Published 2018 Jul 5. doi:10.3389/fnins.2018.00464

[8]Carmen Vida, Irene Martínez de Toda, Julia Cruces, Antonio Garrido, Mónica Gonzalez-Sanchez, Mónica De la Fuente, Role of macrophages in age-related oxidative stress and lipofuscin accumulation in mice, Redox Biology, Volume 12, 2017, Pages 423-437, ISSN 2213-2317, https://doi.org/10.1016/j.redox.2017.03.005.

[9]Lloberas J., Tur J., Vico T., Celada A. (2019) Molecular and Cellular Aspects of Macrophage Aging. In: Fulop T., Franceschi C., Hirokawa K., Pawelec G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-99375-1_46

[10]Connie Jackaman, Federica Tomay, Lelinh Duong, Norbaini Bintu Abdol Razak, Fiona J. Pixley, Pat Metharom, Delia J. Nelson, Aging and cancer: The role of macrophages and neutrophils, Ageing Research Reviews, Volume 36, 2017, Pages 105-116, ISSN 1568-1637, https://doi.org/10.1016/j.arr.2017.03.008.

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