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Could Telomere Length and Lifespan be Enhanced with CRISPR?

Could Telomere Length and Lifespan be Enhanced with CRISPR?

Image credit: Thomas Ried/NCI Center for Cancer Research

By Jamila Ahmed on Jul 28, 2020

[1] Tomás-Loba, Antonia, et al. "Telomerase reverse transcriptase delays aging in cancer-resistant mice." Cell, 135.4, 2008, pp. 609-622.

[2] de Jesus, Bruno Bernardes, et al. "Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer." EMBO molecular medicine, 4.8, 2012, pp. 691-704.

[3] Chiba, Kunitoshi, et al. "Cancer-associated TERT promoter mutations abrogate telomerase silencing." Elife, 4, 2015, pp. e07918.

[4] Lewinska, Anna, et al. "Downregulation of methyltransferase Dnmt2 results in condition‐dependent telomere shortening and senescence or apoptosis in mouse fibroblasts." Journal of cellular physiology, 232.12, 2017, pp. 3714-3726.

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Epigenetic editing to increase Telomerase reverse transcriptase levels: possibilities and concerns

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