Facebook PixelDefining the aging phenotype
Brainstorming
Brainstorming
Brainstorming session

Defining the aging phenotype

Defining the aging phenotype

Image credit: https://youtu.be/Q1CwARpnfe8

By Shubhankar Kulkarni on Jul 28, 2020

[1] Walter S, Atzmon G, Demerath EW, Garcia ME, Kaplan RC, Kumari M, et al. A genome-wide association study of aging. Neurobiol Aging [Internet]. 2011 Nov;32(11):2109.e15-2109.e28. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0197458011002107

[2] Horvath S, Pirazzini C, Bacalini MG, Gentilini D, Di Blasio AM, Delledonne M, et al. Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring. Aging (Albany NY) [Internet]. 2015 Dec 15;7(12):1159–70. Available from: http://www.aging-us.com/article/100861

[3] Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature [Internet]. 1990 May;345(6274):458–60. Available from: http://www.nature.com/articles/345458a0

[4] Li X, Snyder MP. Yeast longevity promoted by reversing aging-associated decline in heavy isotope content. npj Aging Mech Dis [Internet]. 2016 Dec 18;2(1):16004. Available from: http://www.nature.com/articles/npjamd20164

[5] Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, et al. NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science (80- ) [Internet]. 2016 Jun 17;352(6292):1436–43. Available from: https://www.sciencemag.org/lookup/doi/10.1126/science.aaf2693

Creative contributions

Gender specificity of biological age estimation markers

[1] https://academic.oup.com/biomedgerontology/article/74/Supplement_1/S52/5625183

by Juran K. on Oct 27, 2020

Grip strength

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778477/

by Juran K. on Oct 27, 2020

Shubhankar Kulkarni a month ago
Another similar study used 8 different attributes of fitness (muscle strength, endurance, balance, nerve-muscle coordination, agility, core strength, flexibility, and abdominal plsticity) to successfully distinguish between diabetics and non-diabetics. They also propose that increasing the overall fitness score (based on the above-mentioned attributes) helps in alleviating the symptoms of diabetes. I agree, similar reasonable biomarkers can be used to perfectly define age. Reference: https://www.biorxiv.org/content/10.1101/580860v1

Seasonal variances

[1] https://www.nature.com/articles/s41467-020-18758-1

by Juran K. on Oct 27, 2020

Shubhankar Kulkarni a month ago
Juran K. Interesting! I also assume that the changes observed in these biomarkers with the changes in the season will be different in different locations. For example, the study you have cited was performed in California. I think the results may be different in people living in Scandinavia and those from the equatorial region. I tried but could not find another study from a different region.
Juran K. a month ago
Shubhankar Kulkarni I guess they would be different, because the two patterns not only had different peak periods, but also correlated with an average air temperature and average solar radiation (pattern one), or an average air pressure, air humidity, and precipitation (pattern two). So, it is reasonable to think the way you think. It is maybe even predictable.

Biological age estimates using deep phenotyping

[1] https://academic.oup.com/biomedgerontology/article/74/Supplement_1/S52/5625183

by Juran K. on Oct 27, 2020

Glycans as biomarkers of aging

[1] http://tools.thermofisher.com/content/sfs/brochures/BR63722_Glycans_0713S_medium.pdf

[2] https://www.thermofisher.com/hr/en/home/life-science/antibodies/antibodies-learning-center/antibodies-resource-library/antibody-methods/introduction-immunoglobulins.html

[3] https://www.thermofisher.com/hr/en/home/life-science/antibodies/antibodies-learning-center/antibodies-resource-library/antibody-methods/immunoglobulin-igg-class.html

[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049143/

[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049143/

[6] https://glycanage.com

by Juran K. on Oct 28, 2020

Shubhankar Kulkarni a month ago
The second question pinpoints my concern exactly. That is what I want to find out. There are different biomarkers but we need to identify the ones that estimate the "true" biological age. Biological aging can be a point of incidence of frailty or other age-related diseases. Can it be muscle wasting? Reduced functionality of different organs? The more factors we add, the more precise the estimation becomes. However, the more the factors, the more cumbersome is the test, and researchers will avoid it.
Juran K. a month ago
Shubhankar Kulkarni I understand the concern and I understand the idea you have. I agree that more "point of incidence of frailty or other age-related diseases" we have, more precisely we can address the person's current status a.k.a. biological age. One day when the patient's history of disease will be a database connected to his identity, it will be much easier to follow and search for patterns in order to find the ideal points for our "predefined BA ladder".
Now I see I kind of missed the topic with the above contributions, but I hope some of them will be inspirational and helpful.
Shubhankar Kulkarni a month ago
Juran K. Your contributions are biomarkers that are very much needed to define and measure the aging phenotype. When we have a comprehensive list, we can decide (only experimentally), which of these absolutely essential to estimate the biological age. Moreover, it may so happen that we find a correlation across multiple biomarkers mentioned in this session. Then we can use the necessary ones to define the phenotype but use some others to measure it (because they will be easily measurable, non-invasive, etc.).

Methylation of DNA changes as we (and other animals) age

by Brett Melanson on Nov 26, 2020

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