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Brainstorming
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Do primary and secondary senescent cells have different consequences?

Do primary and secondary senescent cells have different consequences?

Image credit: Hoare 2017 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345188/

By Shubhankar Kulkarni on Aug 20, 2020

[1] Moreno-Blas D, Gorostieta-Salas E, Pommer-Alba A, Muciño-Hernández G, Ger�nimo-Olvera C, Maciel-Bar�n LA, et al. Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy. Aging (Albany NY) [Internet]. 2019 Aug 30;11(16). Available from: http://www.aging-us.com/article/102181/text?_escaped_fragment_=

[2] Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, et al. Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence. EMBO J [Internet]. 2019 Mar 8;38(5). Available from: https://onlinelibrary.wiley.com/doi/abs/10.15252/embj.2018100492

[3] Schmeer C, Kretz A, Wengerodt D, Stojiljkovic M, Witte OW. Dissecting Aging and Senescence—Current Concepts and Open Lessons. Cells [Internet]. 2019 Nov 15;8(11):1446. Available from: https://www.mdpi.com/2073-4409/8/11/1446

[4] Hoare M, Narita M. NOTCH and the 2 SASPs of senescence. Cell Cycle [Internet]. 2017 Feb 1;16(3):239–40. Available from: https://www.tandfonline.com/doi/full/10.1080/15384101.2016.1248730

[5] Teo YV, Rattanavirotkul N, Olova N, Salzano A, Quintanilla A, Tarrats N, et al. Notch Signaling Mediates Secondary Senescence. Cell Rep [Internet]. 2019 Apr;27(4):997-1007.e5. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2211124719304516

[6] Hoare M, Ito Y, Kang T-W, Weekes MP, Matheson NJ, Patten DA, et al. NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat Cell Biol [Internet]. 2016 Sep 15;18(9):979–92. Available from: http://www.nature.com/articles/ncb3397

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