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How can we investigate the complexities of neurodegenerative disease?

How can we investigate the complexities of neurodegenerative disease?

Image credit: Stephanie Holst

By Stephanie Holst on Sep 09, 2020

[1] Duyckaerts, C., Delatour, B. & Potier, M. Classification and basic pathology of Alzheimer disease. Acta Neuropathol 118, 5–36 (2009). https://doi.org/10.1007/s00401-009-0532-1

[2] Parsons MP, Kang R, Buren C, et al. Bidirectional control of postsynaptic density-95 (PSD-95) clustering by Huntingtin. J Biol Chem. 2014;289(6):3518-3528. doi:10.1074/jbc.M113.513945

[3] Guan, X.; Fierke, C. A. Understanding Protein Palmitoylation: Biological Significance and Enzymology. Science China Chemistry 2011, 54 (12), 1888–1897. https://doi.org/10.1007/s11426-011-4428-2.

[4] Resh, M. D. Covalent Lipid Modifications of Proteins. Current Biology 2013, 23 (10), R431–R435. https://doi.org/10.1016/j.cub.2013.04.024.

[5] Pizzarelli, R.; Griguoli, M.; Zacchi, P.; Petrini, E. M.; Barberis, A.; Cattaneo, A.; Cherubini, E. Tuning GABAergic Inhibition: Gephyrin Molecular Organization and Functions. Neuroscience 2019. https://doi.org/10.1016/j.neuroscience.2019.07.036.

[6] Fukata, Y.; Fukata, M. Protein Palmitoylation in Neuronal Development and Synaptic Plasticity. Nature Reviews Neuroscience 2010, 11 (3), 161–175. https://doi.org/10.1038/nrn2788.

[7] Greaves, J.; Prescott, G. R.; Gorleku, O. A.; Chamberlain, L. H. The Fat Controller: Roles of Palmitoylation in Intracellular Protein Trafficking and Targeting to Membrane Microdomains (Review). Molecular Membrane Biology 2009, 26 (1–2), 67–79. https://doi.org/10.1080/09687680802620351.

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The isoaspartate modification is involved in Alzheimer’s disease pathology.

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