Facebook PixelHow can we overcome the problem of resistance of the senescent cells to senolytics?
Brainstorming
Brainstorming
Brainstorming session

How can we overcome the problem of resistance of the senescent cells to senolytics?

How can we overcome the problem of resistance of the senescent cells to senolytics?

Image credit: http://www.longlonglife.org/en/transhumanism-longevity/anti-aging-supplements/senolytics-the-war-on-senescence-is-on/

By Apoorva Kulkarni on Sep 25, 2020

[1] Kang C. Senolytics and Senostatics: A Two-Pronged Approach to Target Cellular Senescence for Delaying Aging and Age-Related Diseases. Mol Cells [Internet]. 2019 Dec 31;42(12):821–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/31838837

Creative contributions

Targeting SCAPS

[1] Kirkland, James L., and Tamar Tchkonia. "Senolytic drugs: from discovery to translation." Journal of internal medicine (2020).

[2] Yosef, Reut, et al. "Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL." Nature communications 7.1 (2016): 1-11.

[3] Nakajima, Wataru, et al. "Combination with vorinostat overcomes ABT-263 (navitoclax) resistance of small cell lung cancer." Cancer biology & therapy 17.1 (2016): 27-35.

by Jamila Ahmed on Sep 28, 2020

CAR T cells as Senolytics

[1] Grezella C, Fernandez-Rebollo E, Franzen J, Ventura Ferreira MS, Beier F, Wagner W. Effects of senolytic drugs on human mesenchymal stromal cells. Stem Cell Res Ther. 2018;9(1):108. Published 2018 Apr 18. doi:10.1186/s13287-018-0857-6

[2] Cardiac Glycosides as Senolytic Compounds, Martin, Nadine et al.Trends in Molecular Medicine, Volume 26, Issue 3, 243 – 245

[3] Halim L, Maher J. CAR T-cell immunotherapy of B-cell malignancy: the story so far. Therapeutic Advances in Vaccines and Immunotherapy. January 2020. doi:10.1177/2515135520927164

[4] Amor, C., Feucht, J., Leibold, J. et al. Senolytic CAR T cells reverse senescence-associated pathologies. Nature 583, 127–132 (2020). https://doi.org/10.1038/s41586-020-2403-9

by Antonio Carusillo on Oct 05, 2020

Targeting BCL-XL with CRISPR

[1] Yosef, Reut, et al. "Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL." Nature communications 7.1 (2016): 1-11.

[2] Zhu, Yi, et al. "New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463." Aging (Albany NY) 9.3 (2017): 955.

by Jamila Ahmed on Oct 06, 2020

Combinatorial drug treatment

by Shubhankar Kulkarni on Sep 25, 2020

DNA damage-induced senescence promotes senolytic sensitivity

by Shubhankar Kulkarni on Sep 25, 2020

Your creative contribution

0 / 200

Added via the text editor