Facebook PixelHow could we completely erase the epigenetic marks during cellular reprogramming?
Create new
Sessions onlySessions only
Ideas onlyIdeas only
Brainstorming session

How could we completely erase the epigenetic marks during cellular reprogramming?

Shubhankar Kulkarni
Shubhankar Kulkarni Jul 27, 2020

[1]Mertens J, Paquola ACM, Ku M, Hatch E, Böhnke L, Ladjevardi S, et al. Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. Cell Stem Cell [Internet]. 2015 Dec;17(6):705–18. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1934590915004087

[2]Banito A, Rashid ST, Acosta JC, Li S, Pereira CF, Geti I, et al. Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev [Internet]. 2009 Sep 15;23(18):2134–9. Available from: http://genesdev.cshlp.org/cgi/doi/10.1101/gad.1811609

[3]Lo Sardo V, Ferguson W, Erikson GA, Topol EJ, Baldwin KK, Torkamani A. Influence of donor age on induced pluripotent stem cells. Nat Biotechnol [Internet]. 2017 Jan 12;35(1):69–74. Available from: http://www.nature.com/articles/nbt.3749

[4]Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, et al. Epigenetic memory in induced pluripotent stem cells. Nature [Internet]. 2010 Sep 19;467(7313):285–90. Available from: http://www.nature.com/articles/nature09342

[5]Miura K, Okada Y, Aoi T, Okada A, Takahashi K, Okita K, et al. Variation in the safety of induced pluripotent stem cell lines. Nat Biotechnol [Internet]. 2009 Aug 9;27(8):743–5. Available from: http://www.nature.com/articles/nbt.1554

Creative contributions

Somatic Memory

Jamila Aug 10, 2020

Add your creative contribution

0 / 200

Added via the text editor

* Indicates a required field

By using this platform you agree to our terms of service and privacy policy.

General comments