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How does enhancer hypomethylation affect aging/age-related disorders?

How does enhancer hypomethylation affect aging/age-related disorders?

Image credit: Xia, Ji-Han, and Gong-Hong Wei. https://www.mdpi.com/2073-4409/8/10/1281/htm#

By Aohona Datta on Aug 23, 2020

[1] Kundaje, Anshul, et al. “Integrative Analysis of 111 Reference Human Epigenomes.” Nature, vol. 518, Feb. 2015, pp. 317–30.

[2] Peters, Marjolein J., et al. “The Transcriptional Landscape of Age in Human Peripheral Blood.” Nature Communications, vol. 6, Oct. 2015, p. 8570.

[3] Malik, Athar N., et al. “Genome-Wide Identification and Characterization of Functional Neuronal Activity–Dependent Enhancers.” Nature Neuroscience, vol. 17, Oct. 2014, pp. 1330–39.

[4] Thakurela, Sudhir et al. “Dynamics and function of distal regulatory elements during neurogenesis and neuroplasticity.” Genome research vol. 25, 2015 pp. 1309-24.

[5] Joo, Jae-Yeol, et al. “Stimulus-Specific Combinatorial Functionality of Neuronal c-Fos Enhancers.” Nature Neuroscience, vol. 19, Jan. 2016, pp. 75–83.

[6] Li, Peipei et al. “Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer's disease pathology and cognitive symptoms.” Nature communications vol. 10, 2019.

[7] Adam, Rene C., et al. “Pioneer Factors Govern Super-Enhancer Dynamics in Stem Cell Plasticity and Lineage Choice.” Nature, vol. 521, 2015, pp. 366–70.

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