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How gene editing can address mitochondrial DNA?

How gene editing can address mitochondrial DNA?

Image credit: http://www.cellimagelibrary.org/images/11397

By Antonio Carusillo on Aug 27, 2020

[1] Sun N, Youle RJ, Finkel T. The Mitochondrial Basis of Aging. Mol Cell. 2016;61(5):654-666. doi:10.1016/j.molcel.2016.01.028

[2] Heidi Chial, Ph.D. (Write Science Right) & Joanna Craig, Ph.D. (Write Science Right) © 2008 Nature Education Citation: Chial, H. & Craig, J. (2008) mtDNA and mitochondrial diseases. Nature Education 1(1):217

[3] A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity BY MARTIN JINEK, KRZYSZTOF CHYLINSKI, INES FONFARA, MICHAEL HAUER, JENNIFER A. DOUDNA, EMMANUELLE CHARPENTIER SCIENCE17 AUG 2012 : 816-821

[4] Hirakawa MP, Krishnakumar R, Timlin JA, Carney JP, Butler KS. Gene editing and CRISPR in the clinic: current and future perspectives. Biosci Rep. 2020;40(4):BSR20200127. doi:10.1042/BSR20200127

[5] Gammage PA, Moraes CT, Minczuk M. Mitochondrial Genome Engineering: The Revolution May Not Be CRISPR-Ized. Trends Genet. 2018;34(2):101-110. doi:10.1016/j.tig.2017.11.001

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Using TALEs and Base editing to edit mtDNA

by Antonio Carusillo on Aug 28, 2020

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