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Is Rapamycin the first step towards a longer life?

Is Rapamycin the first step towards a longer life?

By Luis Almeida on Nov 22, 2020

[1] Rožman, P., How Could We Slow or Reverse the Human Aging Process and Extend the Healthy Life Span with Heterochronous Autologous Hematopoietic Stem Cell Transplantation. Rejuvenation Res, 2020. 23(2): p. 159-170.

[2] Sehgal, S.N., H. Baker, and C. Vézina, Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. J Antibiot (Tokyo), 1975. 28(10): p. 727-32.

[3] Laplante, M. and D.M. Sabatini, mTOR signaling in growth control and disease. Cell, 2012. 149(2): p. 274-93.

[4] Seto, B., Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer. Clin Transl Med, 2012. 1(1): p. 29.

[5] Harrison, D.E., et al., Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature, 2009. 460(7253): p. 392-5.

[6] Kapahi, P., et al., Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol, 2004. 14(10): p. 885-90.

[7] Vellai, T., et al., Genetics: influence of TOR kinase on lifespan in C. elegans. Nature, 2003. 426(6967): p. 620.

[8] Bitto, A., et al., Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice. 2016. 5.

[9] Kim, A., Wanted: 10,000 dogs for the largest-ever study on aging in canines, in CNN Health. 2019.

[10] Blagosklonny, M.V., Rapamycin for longevity: opinion article. Aging (Albany NY), 2019. 11(19): p. 8048-8067.

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Darko Savic 20 hours ago
Once we do figure out how Rapamycin leads to slower aging maybe derivatives (rapalogs) will be the way to minimize side effects while retaining the benefits