What do you think about engineering plants for the production of biopharmaceuticals?
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Start the plant pharms, but first solve these riddles:
- How to eliminate the possibility of unintentional and unwanted contact and contamination?
- How to establish universal standards for vaccine-producing plants?
- How to minimize the loss of produced biomolecules/proteins while using plants as producers?
- How to decontaminate the produced proteins from other interfering phytochemicals, and from proteolysis?
- How to keep the native structural and functional in the recombinant proteins, ensuring zero unwanted immunogenicity?
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Fiedler, U., Phillips, J., Artsaenko, O., and Conrad, U. 1997. Optimization of scFv antibody production in transgenic plants. Immunotechnology 3: 205–216.
Bischoff, F., 2004. A top-down view of molecular farming from the pharmaceutical industry: requirements ad expectations. In: Molecular Farming: Plant-Made Pharmaceuticals and Technical Proteins, 267–287. Fischer, R., and Schillberg, S., eds., Wiley-VCH, Weinheim, Germany.
Saint-Jore-Dupas, C., Faye L., and Gomord, V. 2007. From planta to pharma with glycosylation in the toolbox. Trends Biotechnol. 25: 317–323.
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