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What is better to use in health and longevity supplements: whole plant derived compounds or isolated bioactive molecules?

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Ruby Grewal Dec 08, 2020

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[3]Qin S, Huang L, Gong J, et al. Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials. Nutr J. 2017;16(1):68. Published 2017 Oct 11. doi:10.1186/s12937-017-0293-y

[4]Maithili Karpaga Selvi N, Sridhar MG, Swaminathan RP, Sripradha R. Efficacy of Turmeric as Adjuvant Therapy in Type 2 Diabetic Patients. Indian J Clin Biochem. 2015;30(2):180-186. doi:10.1007/s12291-014-0436-2

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[12]Tyagi AK, Prasad S, Yuan W, Li S, Aggarwal BB. Identification of a novel compound (β-sesquiphellandrene) from turmeric (Curcuma longa) with anticancer potential: comparison with curcumin. Invest New Drugs. 2015 Dec;33(6):1175-86. doi: 10.1007/s10637-015-0296-5. Epub 2015 Nov 2. PMID: 26521943.

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[15]Antony B, Merina B, Iyer VS, Judy N, Lennertz K, Joyal S. A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95CG (Biocurcumax), A Novel Bioenhanced Preparation of Curcumin. Indian J Pharm Sci. 2008 Jul-Aug;70(4):445-9. doi: 10.4103/0250-474X.44591. PMID: 20046768; PMCID: PMC2792534.

Creative contributions

Whole plant foods and prebiotics: what we ought not to miss

Subash Chapagain
Subash Chapagain Dec 08, 2020

[1]Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr. 1995 Jun;125(6):1401-12. doi: 10.1093/jn/125.6.1401. PMID: 778289

[2]Gibson G.R., Scott K.P., Rastall R.A., Tuohy K.M., Hotchkiss A., Dubert-Ferrandon A., Gareau M., Murphy E.F., Saulnier D., Loh G., et al. Dietary prebiotics: Current status and new definition. Food Sci. Technol. Bull. Funct. Foods. 2010;7:1–19. doi: 10.1616/1476-2137.

[3]Stinson LF, Payne MS, Keelan JA. Planting the seed: Origins, composition, and postnatal health significance of the fetal gastrointestinal microbiota. Crit Rev Microbiol. 2017 May;43(3):352-369. doi: 10.1080/1040841X.2016.1211088. Epub 2016 Dec 8. PMID: 27931152

[4]Zhou Z, Zhang Y, Zheng P, Chen X, Yang Y. Starch structure modulates metabolic activity and gut microbiota profile. Anaerobe. 2013 Dec;24:71-8. doi: 10.1016/j.anaerobe.2013.09.012. Epub 2013 Oct 7. PMID: 24113693.

[5]den Besten G., van Eunen K., Groen A.K., Venema K., Reijngoud D.-J., Bakker B.M. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J. Lipid Res. 2013;54:2325–2340. doi: 10.1194/jlr.R036012

[6] Smith, S.C., Choy, R., Johnson, S.K., Hall, R.S., Wildeboer‐Veloo, A.C.M. and Welling, G.W. (2006) Lupin kernel fiber consumption modifies faecal microbiota in healthy men as determined by rRNA gene fluorescent in situ hybridization. Eur J Nutr 45, 335–341.

[7]Arshad, N.S., Zaman, S.A., Rawi, M.H. and Sarbini, S.R. (2018) Resistant starch evaluation and in vitro fermentation of lemantak (native sago starch), for prebiotic assessment. Int Food Res J 25, 951–957.

[8] Havenaar R., Bonnin-Marol S., Van Dokkum W., Petitet S., Schaafsma G. Inulin: Fermentation and microbial ecology in the intestinal tract. Food Rev. Int. 1999;15:109–120. doi: 10.1080/87559129909541179.

Ruby Grewala month ago
Prebiotics and probiotics are another great example. While it is important to understand the effect of each individual product or molecule on human health, if we are talking about getting a supplement approved that has significant benefit for human longevity, it will most likely require a combinatorial approach.

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