Facebook PixelWhat is better to use in health and longevity supplements: whole plant derived compounds or isolated bioactive molecules?
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What is better to use in health and longevity supplements: whole plant derived compounds or isolated bioactive molecules?

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RG
Ruby Grewal Dec 08, 2020

[1]He Y, Yue Y, Zheng X, Zhang K, Chen S, Du Z. Curcumin, inflammation, and chronic diseases: how are they linked?. Molecules. 2015;20(5):9183-9213. Published 2015 May 20. doi:10.3390/molecules20059183

[2]Akuri MC, Barbalho SM, Val RM, Guiguer EL. Reflections about Osteoarthritis and Curcuma longa. Pharmacogn Rev. 2017;11(21):8-12. doi:10.4103/phrev.phrev_54_16

[3]Qin S, Huang L, Gong J, et al. Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials. Nutr J. 2017;16(1):68. Published 2017 Oct 11. doi:10.1186/s12937-017-0293-y

[4]Maithili Karpaga Selvi N, Sridhar MG, Swaminathan RP, Sripradha R. Efficacy of Turmeric as Adjuvant Therapy in Type 2 Diabetic Patients. Indian J Clin Biochem. 2015;30(2):180-186. doi:10.1007/s12291-014-0436-2

[5]Sharma RA, McLelland HR, Hill KA, Ireson CR, Euden SA, Manson MM, Pirmohamed M, Marnett LJ, Gescher AJ, Steward WP. Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin Cancer Res. 2001 Jul;7(7):1894-900. PMID: 11448902.

[6]Ma XW, Guo RY. Dose-dependent effect of Curcuma longa for the treatment of Parkinson's disease. Exp Ther Med. 2017;13(5):1799-1805. doi:10.3892/etm.2017.4225

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[9]Carroll RE, Benya RV, Turgeon DK, et al. Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia [published correction appears in Cancer Prev Res (Phila). 2012 Dec;5(12):1407. Dosage error in article text]. Cancer Prev Res (Phila). 2011;4(3):354-364. PMID: 21372035. PMCID: PMC4136551. doi:10.1158/1940-6207.CAPR-10-0098.

[10]Takada Y, Bhardwaj A, Potdar P, Aggarwal BB. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene. 2004 Dec 9;23(57):9247-58. doi: 10.1038/sj.onc.1208169. PMID: 15489888.

[11]Kim JH, Gupta SC, Park B, Yadav VR, Aggarwal BB. Turmeric (Curcuma longa) inhibits inflammatory nuclear factor (NF)-κB and NF-κB-regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis. Mol Nutr Food Res. 2012;56(3):454-465. doi:10.1002/mnfr.201100270

[12]Tyagi AK, Prasad S, Yuan W, Li S, Aggarwal BB. Identification of a novel compound (β-sesquiphellandrene) from turmeric (Curcuma longa) with anticancer potential: comparison with curcumin. Invest New Drugs. 2015 Dec;33(6):1175-86. doi: 10.1007/s10637-015-0296-5. Epub 2015 Nov 2. PMID: 26521943.

[13]Arun N, Nalini N. Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Foods Hum Nutr. 2002 Winter;57(1):41-52. doi: 10.1023/a:1013106527829. PMID: 11855620.

[14]Wright LE, Frye JB, Timmermann BN, Funk JL. Protection of trabecular bone in ovariectomized rats by turmeric (Curcuma longa L.) is dependent on extract composition. J Agric Food Chem. 2010;58(17):9498-9504. doi:10.1021/jf101873f

[15]Antony B, Merina B, Iyer VS, Judy N, Lennertz K, Joyal S. A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95CG (Biocurcumax), A Novel Bioenhanced Preparation of Curcumin. Indian J Pharm Sci. 2008 Jul-Aug;70(4):445-9. doi: 10.4103/0250-474X.44591. PMID: 20046768; PMCID: PMC2792534.

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Creative contributions

Whole plant foods and prebiotics: what we ought not to miss

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Subash Chapagain
Subash Chapagain Dec 08, 2020

[1]Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr. 1995 Jun;125(6):1401-12. doi: 10.1093/jn/125.6.1401. PMID: 778289

[2]Gibson G.R., Scott K.P., Rastall R.A., Tuohy K.M., Hotchkiss A., Dubert-Ferrandon A., Gareau M., Murphy E.F., Saulnier D., Loh G., et al. Dietary prebiotics: Current status and new definition. Food Sci. Technol. Bull. Funct. Foods. 2010;7:1–19. doi: 10.1616/1476-2137.

[3]Stinson LF, Payne MS, Keelan JA. Planting the seed: Origins, composition, and postnatal health significance of the fetal gastrointestinal microbiota. Crit Rev Microbiol. 2017 May;43(3):352-369. doi: 10.1080/1040841X.2016.1211088. Epub 2016 Dec 8. PMID: 27931152

[4]Zhou Z, Zhang Y, Zheng P, Chen X, Yang Y. Starch structure modulates metabolic activity and gut microbiota profile. Anaerobe. 2013 Dec;24:71-8. doi: 10.1016/j.anaerobe.2013.09.012. Epub 2013 Oct 7. PMID: 24113693.

[5]den Besten G., van Eunen K., Groen A.K., Venema K., Reijngoud D.-J., Bakker B.M. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J. Lipid Res. 2013;54:2325–2340. doi: 10.1194/jlr.R036012

[6] Smith, S.C., Choy, R., Johnson, S.K., Hall, R.S., Wildeboer‐Veloo, A.C.M. and Welling, G.W. (2006) Lupin kernel fiber consumption modifies faecal microbiota in healthy men as determined by rRNA gene fluorescent in situ hybridization. Eur J Nutr 45, 335–341.

[7]Arshad, N.S., Zaman, S.A., Rawi, M.H. and Sarbini, S.R. (2018) Resistant starch evaluation and in vitro fermentation of lemantak (native sago starch), for prebiotic assessment. Int Food Res J 25, 951–957.

[8] Havenaar R., Bonnin-Marol S., Van Dokkum W., Petitet S., Schaafsma G. Inulin: Fermentation and microbial ecology in the intestinal tract. Food Rev. Int. 1999;15:109–120. doi: 10.1080/87559129909541179.

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RG
Ruby Grewala month ago
Prebiotics and probiotics are another great example. While it is important to understand the effect of each individual product or molecule on human health, if we are talking about getting a supplement approved that has significant benefit for human longevity, it will most likely require a combinatorial approach.

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