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Which theory of aging best explains why we grow old?

Darko Savic
Darko Savic Jul 26, 2020

[1]Galkin F, Zhang B, Dmitriev SE, Gladyshev VN. Reversibility of irreversible aging. Ageing Res Rev [Internet]. 2019 Jan;49:104–14. https://linkinghub.elsevier.com/retrieve/pii/S156816371830254X

[2]Campisi J. Aging, Cellular Senescence, and Cancer. Annu Rev Physiol [Internet]. 2013 Feb 10;75(1):685–705. http://www.annualreviews.org/doi/10.1146/annurev-physiol-030212-183653

[3]Sapieha P, Mallette FA. Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest. Trends Cell Biol [Internet]. 2018 Aug;28(8):595–607. https://linkinghub.elsevier.com/retrieve/pii/S096289241830059X

[4]McHugh D, Gil J. Senescence and aging: Causes, consequences, and therapeutic avenues. J Cell Biol [Internet]. 2018 Jan 2;217(1):65–77. https://rupress.org/jcb/article/217/1/65/39207/Senescence-and-aging-Causes-consequences-and

[5]Schmeer C, Kretz A, Wengerodt D, Stojiljkovic M, Witte OW. Dissecting Aging and Senescence - Current Concepts and Open Lessons. Cells (Internet). 2019 Nov 15;8(11):1446. https://www.mdpi.com/2073-4409/8/11/1446

[6]Goldsmith TC. Evolution of aging theories: Why modern programmed aging concepts are transforming medical research. Biochem [Internet]. 2016 Dec 18;81(12):1406–12. http://link.springer.com/10.1134/S0006297916120026

[7]Salminen A, Kauppinen A, Kaarniranta K. Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP). Cell Signal [Internet]. 2012 Apr;24(4):835–45. https://linkinghub.elsevier.com/retrieve/pii/S0898656811003846

[8]Gladyshev VN. Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes. Aging Cell [Internet]. 2016 Aug;15(4):594–602. http://doi.wiley.com/10.1111/acel.12480

[9]Salminen A, Ojala J, Huuskonen J, Kauppinen A, Suuronen T, Kaarniranta K. Interaction of aging-associated signaling cascades: Inhibition of NF-κB signaling by longevity factors FoxOs and SIRT1. Cell Mol Life Sci [Internet]. 2008 Apr 15;65(7–8):1049–58. http://link.springer.com/10.1007/s00018-008-7461-3

Creative contributions

Entropy and hormesis

Darko Savic
Darko Savic Dec 02, 2020

Only two theories

Dragan Otasevic
Dragan Otasevic Sep 30, 2020

Programmed Theory

Mohammad Shazaib
Mohammad Shazaib Sep 30, 2020

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