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Which theory of aging best explains why we grow old?

Which theory of aging best explains why we grow old?

By Darko Savic on Jul 26, 2020

[1] Galkin F, Zhang B, Dmitriev SE, Gladyshev VN. Reversibility of irreversible aging. Ageing Res Rev [Internet]. 2019 Jan;49:104–14. https://linkinghub.elsevier.com/retrieve/pii/S156816371830254X

[2] Campisi J. Aging, Cellular Senescence, and Cancer. Annu Rev Physiol [Internet]. 2013 Feb 10;75(1):685–705. http://www.annualreviews.org/doi/10.1146/annurev-physiol-030212-183653

[3] Sapieha P, Mallette FA. Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest. Trends Cell Biol [Internet]. 2018 Aug;28(8):595–607. https://linkinghub.elsevier.com/retrieve/pii/S096289241830059X

[4] McHugh D, Gil J. Senescence and aging: Causes, consequences, and therapeutic avenues. J Cell Biol [Internet]. 2018 Jan 2;217(1):65–77. https://rupress.org/jcb/article/217/1/65/39207/Senescence-and-aging-Causes-consequences-and

[5] Schmeer C, Kretz A, Wengerodt D, Stojiljkovic M, Witte OW. Dissecting Aging and Senescence - Current Concepts and Open Lessons. Cells (Internet). 2019 Nov 15;8(11):1446. https://www.mdpi.com/2073-4409/8/11/1446

[6] Goldsmith TC. Evolution of aging theories: Why modern programmed aging concepts are transforming medical research. Biochem [Internet]. 2016 Dec 18;81(12):1406–12. http://link.springer.com/10.1134/S0006297916120026

[7] Salminen A, Kauppinen A, Kaarniranta K. Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP). Cell Signal [Internet]. 2012 Apr;24(4):835–45. https://linkinghub.elsevier.com/retrieve/pii/S0898656811003846

[8] Gladyshev VN. Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes. Aging Cell [Internet]. 2016 Aug;15(4):594–602. http://doi.wiley.com/10.1111/acel.12480

[9] Salminen A, Ojala J, Huuskonen J, Kauppinen A, Suuronen T, Kaarniranta K. Interaction of aging-associated signaling cascades: Inhibition of NF-κB signaling by longevity factors FoxOs and SIRT1. Cell Mol Life Sci [Internet]. 2008 Apr 15;65(7–8):1049–58. http://link.springer.com/10.1007/s00018-008-7461-3

Creative contributions

Only two theories

by Dragan Otasevic on Sep 30, 2020

Programmed Theory

by Mohammad Shazaib on Sep 30, 2020

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