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Why people taking same dose of Rapamycin have different blood Rapamycin concentrations?

Why people taking same dose of Rapamycin have different blood Rapamycin concentrations?

Image credit: Katherine Hughes et al., 2012 https://science.sciencemag.org/content/335/6076/1578/tab-figures-data

By Shubhankar Kulkarni on Aug 05, 2020

[1] Blagosklonny M V. Rapamycin for longevity: opinion article. Aging (Albany NY) [Internet]. 2019 Oct 4;11(19):8048–67. Available from: http://www.aging-us.com/article/102355/text

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Darko Savic 2 months ago

I would imagine that this is the case with every substance we consume. I look at the human body as one large bioreactor with countless simultaneous chemical reactions continuously taking place since the zygote stage. Even though development follows a "recipe", the product is somewhat unique because it came from so many variables. Everyone is a differently built bioreactor that came from roughly the same plan but made by different crews in different environments :) ...