We've posted a few ideas with a similar general concept. This one is about changing your armpit microbiome. You would kill off all bad-odor producing microorganisms and inoculate the area with microbial species that produce no noticeable smell.
Designer-fragrance producing bacteria
If we take this one step further, the armpits could be inoculated with genetically engineered bacteria that produce pleasant fragrances. A person could effectively order designer microbes to replace the use of perfumes and deodorants. By doing some mix/matching one could design their own, person-specific, pleasant fragrance.
DIY armpit therapy
Until designer-fragrance-producing organisms become available, this idea could be put to use in a do-it-yourself setting:
Kill off your armpit bacteria by applying a few days (weeks?) long therapy comprised of several different agents: a strong antiseptic, MRSA decolonizing mouthwash, a few hours later followed by an antibiotic cream, a few hours later followed by an antifungal cream, a few hours later followed by a cream based on Hypochlorous acid (HOCl) - you get the picture, the therapy would be spaced out and use different over the counter agents that would cumulatively prevent resistance-building in the existing armpit microbiome.
Find a donor who never smells bad. Even if they don't take showers in between work-outs. Have them wear a sterile cotton-based pad under their armpit for a few hours to inoculate it with their armpit microbiome.
Wear the inoculated pad overnight to seed the "good" bacteria under your own armpit.
Keep repeating for a few weeks.
Voila. A brand new armpit microbiome:)
Experimental treatment for Hidradenitis suppurativa
Hidradenitis suppurativa (HS) also known as acne inversa is a nasty and so far incurable disease. The cause remains unknown, and experts disagree over proposed causes.
It would be interesting to see how a microbiome change would affect an individual with HS. It would be even better if before the treatment the existing microbial species were examined. Matching bacteriophage viruses could be found that specifically target the existing bacterial species. Those bacteriophages could be included in the eradication treatment.