Gene therapy to restore color vision in adults may be more effective if Oct4, Sox2, and Klf4 genes are expressed
Image credit: BCM Families Foundation
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- Restoring color vision with gene therapies seems to be doable in children, but it gets more difficult in adults because they've lost the necessary neuronal plasticity. Including the expression of OSK could fix this.
- Color vision restoration gene therapy is possible but not yet safe. By the time it becomes safe it could be too late for adults (who are still children today). Today it's possible but not safe, in the near future it will be safe but not possible (in adults). This idea might solve the paradox.
Fischer MD, Michalakis S, Wilhelm B, et al. Safety and Vision Outcomes of Subretinal Gene Therapy Targeting Cone Photoreceptors in Achromatopsia: A Nonrandomized Controlled Trial. JAMA Ophthalmol. 2020;138(6):643–651. doi:10.1001/jamaophthalmol.2020.1032
Lu, Y., Brommer, B., Tian, X. et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature 588, 124–129 (2020). https://doi.org/10.1038/s41586-020-2975-4
Polunin GS, Nurieva SM, Baiandin DL, Sheremet NL, Andreeva LA. Opredelenie terapevticheskoĭ éffektivnosti novogo otechestvennogo preparata "Semaks" pri zabolevaniiakh zritel'nogo nerva [Evaluation of therapeutic effect of new Russian drug semax in optic nerve disease]. Vestn Oftalmol. 2000 Jan-Feb;116(1):15-8. Russian. PMID: 10741256.