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How could we completely erase the epigenetic marks during cellular reprogramming?

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Shubhankar Kulkarni
Shubhankar Kulkarni Jul 27, 2020

[1]Mertens J, Paquola ACM, Ku M, Hatch E, Böhnke L, Ladjevardi S, et al. Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. Cell Stem Cell [Internet]. 2015 Dec;17(6):705–18. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1934590915004087

[2]Banito A, Rashid ST, Acosta JC, Li S, Pereira CF, Geti I, et al. Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev [Internet]. 2009 Sep 15;23(18):2134–9. Available from: http://genesdev.cshlp.org/cgi/doi/10.1101/gad.1811609

[3]Lo Sardo V, Ferguson W, Erikson GA, Topol EJ, Baldwin KK, Torkamani A. Influence of donor age on induced pluripotent stem cells. Nat Biotechnol [Internet]. 2017 Jan 12;35(1):69–74. Available from: http://www.nature.com/articles/nbt.3749

[4]Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, et al. Epigenetic memory in induced pluripotent stem cells. Nature [Internet]. 2010 Sep 19;467(7313):285–90. Available from: http://www.nature.com/articles/nature09342

[5]Miura K, Okada Y, Aoi T, Okada A, Takahashi K, Okita K, et al. Variation in the safety of induced pluripotent stem cell lines. Nat Biotechnol [Internet]. 2009 Aug 9;27(8):743–5. Available from: http://www.nature.com/articles/nbt.1554

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