How does enhancer hypomethylation affect aging/age-related disorders?
Image credit: Xia, Ji-Han, and Gong-Hong Wei. https://www.mdpi.com/2073-4409/8/10/1281/htm#
Please leave the feedback on this challenge
Is the problem still unsolved?
Is it concisely described?
Bounty for the best solution
Provide a bounty for the best solution
Bounties attract serious brainpower to the challenge.
Kundaje, Anshul, et al. “Integrative Analysis of 111 Reference Human Epigenomes.” Nature, vol. 518, Feb. 2015, pp. 317–30.
Peters, Marjolein J., et al. “The Transcriptional Landscape of Age in Human Peripheral Blood.” Nature Communications, vol. 6, Oct. 2015, p. 8570.
Malik, Athar N., et al. “Genome-Wide Identification and Characterization of Functional Neuronal Activity–Dependent Enhancers.” Nature Neuroscience, vol. 17, Oct. 2014, pp. 1330–39.
Thakurela, Sudhir et al. “Dynamics and function of distal regulatory elements during neurogenesis and neuroplasticity.” Genome research vol. 25, 2015 pp. 1309-24.
Joo, Jae-Yeol, et al. “Stimulus-Specific Combinatorial Functionality of Neuronal c-Fos Enhancers.” Nature Neuroscience, vol. 19, Jan. 2016, pp. 75–83.
Li, Peipei et al. “Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer's disease pathology and cognitive symptoms.” Nature communications vol. 10, 2019.
Adam, Rene C., et al. “Pioneer Factors Govern Super-Enhancer Dynamics in Stem Cell Plasticity and Lineage Choice.” Nature, vol. 521, 2015, pp. 366–70.