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How to avoid gene transfer (via jumping genes) when using GMOs?

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Shubhankar Kulkarni
Shubhankar Kulkarni Aug 07, 2020

[1]Reply by @AntiAgify https://twitter.com/JanieHsieh/status/1291057092586098689?s=20

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Daisy-drive systems

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AK
Apoorva Kulkarni Aug 12, 2020

Silencing the jumping genes if not totally avoiding them

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Subash Chapagain
Subash Chapagain Oct 03, 2020

[1]Rošic, S. et al. Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity. Nat. Genet. 50, 452–459 (2018).

[2]Kim, M. Y. & Zilberman, D. DNA methylation as a system of plant genomic immunity. Trends Plant Sci. 19, 320–326 (2014).

[3]Girard A, Sachidanandam R, Hannon GJ, Carmell MA. A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature. 2006;442(7099):199–202. doi:10.1038/nature04917

[4]Aravin, A. A. et al. A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol. Cell 31, 785–799 (2008).

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Shubhankar Kulkarni
Shubhankar Kulkarni5 months ago
Great idea Subash! Will the methyation by the DNMT be localized to the transposable element gene? Will upregulation affect methylation patterns in the neighboring genes and lead to detrimental effects? I think using piRNAs is more beneficial since it is a targeted therapy and will probably have less "side-effects".

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Darko Savic
Darko Savic6 months ago
I guess we will see soon enough how this unfolds. Here we go https://www.sciencenews.org/article/genetically-modified-mosquitoes-florida-test-release