How to avoid gene transfer (via jumping genes) when using GMOs?
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Reply by @AntiAgify https://twitter.com/JanieHsieh/status/1291057092586098689?s=20
Silencing the jumping genes if not totally avoiding them
- Upregulation of DNA methyltransferase (DNMT) for 5-Methyl-Cytosine (5mC)mediated silencing of transposable elements
- De novo TE silencing using piRNAs
Rošic, S. et al. Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity. Nat. Genet. 50, 452–459 (2018).
Kim, M. Y. & Zilberman, D. DNA methylation as a system of plant genomic immunity. Trends Plant Sci. 19, 320–326 (2014).
Girard A, Sachidanandam R, Hannon GJ, Carmell MA. A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature. 2006;442(7099):199–202. doi:10.1038/nature04917
Aravin, A. A. et al. A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol. Cell 31, 785–799 (2008).