How to avoid gene transfer (via jumping genes) when using GMOs?
Image credit: https://www.google.com/url?sa=i&url=https%3A%2F%2Fcollapseofindustrialcivilization.com%2Ftag%2Fgmo%2F&psig=AOvVaw28D58UtsSJzCJ52rQlcOkf&ust=1596887142894000&source=images&cd=vfe&ved=0CA0QjhxqFwoTCNCzw6yCiesCFQAAAAAdAAAAABAQ
Please leave the feedback on this session
Is the problem still unsolved?
Is it concisely described?
Reply by @AntiAgify https://twitter.com/JanieHsieh/status/1291057092586098689?s=20
Please leave the feedback on this
Silencing the jumping genes if not totally avoiding them
- Upregulation of DNA methyltransferase (DNMT) for 5-Methyl-Cytosine (5mC)mediated silencing of transposable elements
- De novo TE silencing using piRNAs
Rošic, S. et al. Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity. Nat. Genet. 50, 452–459 (2018).
Kim, M. Y. & Zilberman, D. DNA methylation as a system of plant genomic immunity. Trends Plant Sci. 19, 320–326 (2014).
Girard A, Sachidanandam R, Hannon GJ, Carmell MA. A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature. 2006;442(7099):199–202. doi:10.1038/nature04917
Aravin, A. A. et al. A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol. Cell 31, 785–799 (2008).