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Limb regeneration: what are the problems/knowledge gaps that need to be solved?

Image credit: James Monaghan laboratory/Northeastern University

Shubhankar Kulkarni
Shubhankar Kulkarni Sep 03, 2020

[1]1. Fakorede, F. A. (2018). "Increasing awareness about peripheral artery disease can save limbs and lives." Am J Manag Care 24 (14 Spec No.): SP609.

Creative contributions

What is the process in which the cells used to make the blastema dedifferentiate and then become differentiated once again?

Jamila Sep 03, 2020

[1]Abo‐Al‐Ela, Haitham G., and Mario A. Burgos‐Aceves. "Exploring the role of microRNAs in axolotl regeneration." Journal of Cellular Physiology (2020).

[2]King, Benjamin L., and Viravuth P. Yin. "A conserved microRNA regulatory circuit is differentially controlled during limb/appendage regeneration." PLoS One 11.6 (2016): e0157106.

[3]Holman, Edna C., et al. "Microarray analysis of microRNA expression during axolotl limb regeneration." PLoS One 7.9 (2012): e41804.

Challenges limitations and a possible strategy to Endogenous tissues regeneration

Antonio Carusillo
Antonio Carusillo Sep 05, 2020

Modulating the immune response to limb amputation

Aohona Datta Sep 06, 2020

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General comments

Darko Savic
Darko Savic4 months ago
Here's a cool video lecture on this topic https://youtu.be/x0bYOUmwCGk