Facebook PixelPersonalized on-a-chip test for inhalation allergies
Create newCreate new

Personalized on-a-chip test for inhalation allergies

jnikola May 11, 2022
Please leave the feedback on this idea

Is it original or innovative?


Is it feasible?


Is it targeting an unsolved problem?


Is it concisely described?

Bounty for the best solution

Provide a bounty for the best solution

Bounties attract serious brainpower to the challenge.

Currency *
Who gets the Bounty *
Allergic rhinitis can occur as a systemic allergy with systemic atopy and a positive skin prick/blood test or as local allergic rhinitis (LAR) as a local allergic reaction affecting only the nasal mucosa without systemic atopy.
==> A simple test that tests the sensitivity of a patient's nose and sinuses epithelial cells to inhalation allergens. In other words, a test that can detect nasal LAR.

There are no existing tests that can easily and specifically test patients' sensitivity to inhalation allergens and therefore help identify inhalation allergens causing allergic rhinitis.
How would it work?
  1. Patients with suspected allergies to inhalation allergens would come to the hospital and have their nasal epithelial cells isolated and cultured as described by Hussain et al (2013) .
  2. Patients nasal epithelial cells would then be seeded into specially designed microfluidics chips (Figure 1). The chip would be designed to have multiple channels for multiple allergen testing in the same time (Figure 2). The allergens would be introduced by air to simulate inhalation allergen effect on nasal mucus. After every reaction, nasal mucus would be collected and washed with saline.
  3. Measuring parameters would be objective and would consist of technical characteristics like volume of the channel, secreted nasal mucus volume, time fo reaction, response to increasing concentrations of allergen (determining the triggering concentration), with additional chemical and biological analysis of the secreted mucus (diagnostic phase) and cells which could later be lysed and their DNA/RNA sequenced to look for changed genes or pathways (research phase). Since different measuring systems can be implemented on a chip, different characteristics could be tracked during exposure to allergens (molecules in the exiting air, different temperatures of the air, etc).
Figure 1. Concept of nasal-mucus-on-a-chip showed on an example of lung-on-a-chip
Figure 2. Microfluidics multi-channel polymer chip
It could also be used for nonallergic rhinitis trigger detection, too, by applying different conditions mimicking weather conditions, infections, medications, hormone changes, etc. It could serve as a drug testing tool by applying inhalation or liquid drugs on a specific patient's cells.

Additional information
Allergies are hypersensitive disorders of the immune system. Basically, your system reacts to non-harmful allergens. Allergens can enter human body through:
  • skin (contact allergens; latex gloves, jewelery jewelrychemicals, etc.)
  • ingestion (food, drugs)
  • injection (medications, bee sting)
  • inhalation (pollens, dust, mold, animal dander, etc.)
Allergic rhinitis is an allergic reaction caused by the inhalation of the particles such as pollen, dust mites or tiny flecks of skin and saliva shed by cats, dogs and other animals with fur or feathers .
Current allergy tests can be divided on:
  • skin tests
  • Skin prick test (SPT) - tests IgE mediated type I allergic reactions (allergic rhynitis, atopic asthma, acute urticaria, food allergy, etc.); study showed that SPT alone was capable of detecting only 68.5% of allergic rhinitis patients
  • Intradermal skin tests (ID) - same as the above, but the antigen is injected in the outer layer of the skin
  • Patch test - investigation of the antigens causing contact dermatitis
  • blood tests
  • Total serum IgE - scanning blood for specific antibodies
  • challenge tests - you are challenged to ingest an increasing amounts of the suspected allergen under doctor's supervision
  • other specific allergic rhinitis tests:
Nasal alergen provocation test (NAPT)
It uses real-time response to allergens to determine the local allergic response by measuring subjective (nasal obstruction, rhinorrhea, itching, sneezing, and ocular symptoms were recorded by using a visual analog scale (VAS)) and objective (nasal patency measured by acoustic rhinometry) parameters .
Minuses: many factors can affect local allergic reaction, only one (or a few) allergens at a time, not a safe method of testing patients with strong allergic reactions











Creative contributions
Know someone who can contribute to this idea? Share it with them on , , or

Add your creative contribution

0 / 200

Added via the text editor

Sign up or


Guest sign up

* Indicates a required field

By using this platform you agree to our terms of service and privacy policy.

General comments