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Whole-tooth regeneration: what are the problems/knowledge gaps that need to be solved?

Image credit: Dr. Alan Carr, https://creativecommons.org/licenses/by/2.0/

Shubhankar Kulkarni
Shubhankar Kulkarni Sep 07, 2020

[1]Balic A. Biology Explaining Tooth Repair and Regeneration: A Mini-Review. Gerontology [Internet]. 2018;64(4):382–8. Available from: https://www.karger.com/Article/FullText/486592

[2]Smith EE, Yelick PC. Progress in Bioengineered Whole Tooth Research: from Bench to Dental Patient Chair. Curr Oral Heal Reports [Internet]. 2016 Dec 5;3(4):302–8. Available from: http://link.springer.com/10.1007/s40496-016-0110-2

[3]Mitsiadis TA, Harada H. Regenerated teeth: the future of tooth replacement. An update. Regen Med [Internet]. 2015 Jan;10(1):5–8. Available from: https://www.futuremedicine.com/doi/10.2217/rme.14.78

[4]Yang L, Angelova Volponi A, Pang Y, Sharpe PT. Mesenchymal Cell Community Effect in Whole Tooth Bioengineering. J Dent Res [Internet]. 2017 Feb 7;96(2):186–91. Available from: http://journals.sagepub.com/doi/10.1177/0022034516682001

Creative contributions

Using mesenchymal stem cells and 3D-tissue engineering

Antonio Carusillo
Antonio Carusillo Sep 12, 2020

Could human deciduous pulp stem cell (hDPSC) implantation be used?

Subash Chapagain
Subash Chapagain Oct 15, 2020

[1]Miura, M., Gronthos, S., Zhao, M., Lu, B., Fisher, L. W., Robey, P. G., & Shi, S. (2003). SHED: Stem cells from human exfoliated deciduous teeth. Proceedings of the National Academy of Sciences, 100(10), 5807–5812. https://doi.org/10.1073/pnas.0937635100

[2]Xuan, K., Li, B., Guo, H., Sun, W., Kou, X., He, X., Zhang, Y., Sun, J., Liu, A. Liao, L., Liu, S., Liu, W., Hu, C., Shi, S., & Jin, Y. (2018). Deciduous autologous tooth stem cells regenerate dental pulp after implantation into injured teeth. Science Translational Medicine, 10(455), eaaf3227. https://doi.org/10.1126/scitranslmed.aaf3227

[3]Prescott RS, Alsanea R, Fayad MI, et al. In vivo generation of dental pulp‐like tissue by using dental pulp stem cells, a collagen scaffold, and dentin matrix protein 1 after subcutaneous transplantation in mice. J Endod. 2008;34(4):421‐426.

[4]Cordeiro MM, Dong Z, Kaneko T, et al. Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth. J Endod. 2008;34(8):962‐969.

Find Out How Supernumerary Teeth Are Generated

Jamila Sep 07, 2020

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General comments

Darko Savic
Darko Savic25 days ago
Sounds like we are 30% there https://youtu.be/en79wtbytvk

The video is referring to this Chinese study https://stm.sciencemag.org/content/10/455/eaaf3227