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A novel endometriosis blood test

Image credit: National Cancer Institute

Jamila Feb 01, 2021

[1]Karimi-Zarchi, Mojgan, et al. "Correlation of CA-125 serum level and clinico-pathological characteristic of patients with endometriosis." International Journal of Reproductive BioMedicine 14.11 (2016): 713.

[2]Perricos, Alexandra, et al. "Increased serum levels of mBDNF in women with minimal and mild endometriosis have no predictive power for the disease." Experimental Biology and Medicine 243.1 (2018): 50-56.

[3]Moustafa, Sarah, et al. "Accurate diagnosis of endometriosis using serum microRNAs." American journal of obstetrics and gynecology 223.4 (2020): 557-e1.

[4]Hussein, Shatha Sami, Fatin Shallal Farhan, and Alaa Ibrahim Ali. "Serum Leptin as a Marker for Severity of Endometriosis." Obstetrics and Gynecology International 2020 (2020).

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General comments

Dragan Otasevic
Dragan Otasevica month ago
Jamila this idea easily fits on the list of top biotech startup ideas https://brainstorming.com/sessions/a-growing-list-of-top-biotech-startup-ideas/51
Shubhankar Kulkarni
Shubhankar Kulkarnia month ago
Great idea Jamila ! In addition to the set of genes you have posted in the session text that can be used as biomarkers for diagnosing endometriosis, this paper offers some (https://academic.oup.com/endo/article/148/8/3814/2502189). They studied the entire transcriptome and compared those of women with and without endometriosis. They saw changes in a number of genes. For the full set of genes, please take a look at the paper. I will mention a few genes here whose mRNA levels changed more than 5-fold in women with endometriosis, which is highly significant.

Genes that were upregulated in women with endometriosis:
Topoisomerase (DNA) IIα, 170 kDa
RAB6 interacting, kinesin-like
Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
T-LAK cell-originated protein kinase

Genes that were downregulated in women with endometriosis:
Metallothionein 1Y
CXCL13: chemokine ligand 13 (B-cell chemoattractant)
Cytochrome P450, subfamily XXVIA
Secretoglobin, family 2A, member 2
Metallothionein 1G

As an alternative to the blood test, the transcripts can be tagged with a dye (https://www.researchgate.net/publication/6226209_Cell-specific_microarray_profiling_experiments_reveal_a_comprehensive_picture_of_gene_expression_in_the_C_elegans_nervous_system/figures?lo=1, https://www.biorxiv.org/content/biorxiv/early/2018/03/30/292441.full.pdf). The solution that contains the dye attached to a reverse transcript of the one of interest can be ingested and the radiography can reveal the concentration (severity or the phase of endometriosis) and the location (outside the uterus, fallopian tubes, ovaries, etc.)