This would be necessary in order to truly appeal to fans, at least initially, unless the creators have a massive budget and own/control all IP like Disney, who can therefore fully control all aspects of Disneyland for full immersion and ensure a level of consistency between shows.
For those without that kind of budget, if we do really want to integrate more than one “world” it would likely be important to keep clear segregation between where each new world starts.
This might be easier to accomplish with different arcs of the same universe than with vastly different universes, such as there could be an "old quarter" or "future quarter" etc for such multiverses as Spiderman or X-men, and therefore pay homage to these different concepts separately rather than trying to merge them, as this can easily lead fans to become upset or accuse creators of "selling out" their particular "original" or "true" fandom for money, as fandoms are often extremely territorial and protective about the integrity of their beloved franchises.
A recent example of how fan nostalgia is often transformed into conflict is the conflict between fans of the old vs new She-ra series even online. Trying to reconcile two completely different aesthetics, character takes and storylines in the same place which are so incompatible would very much annoy both fandoms and make the design work very sloppy in trying to architect a compromise.
This would be an example of where, unlike the spiderman "multiverse", you would want to make the segregation between two different concepts particularly clear if you do want to encompass both, or else just pick which universe you are representing and make it clear you are going with that one, to avoid angering the fans, as one thing fans love is consistency around "their" franchise.
Even as a kid, I remember being disappointed when toys didn't match the characters in the shows in exact detail (down to hair colour, accessories or even imperfections in the paintwork) and that probably was the reason I became very averse to buying fan merchandise. I only overcame this as an adult and found myself far more willing to support a franchise financially when I saw up close how much attention to detail went into making the toy figurines exactly match the characters of the show. And even as an adult I find myself very tempted to distance myself from bad reworkings of some of my beloved franchises which have been through multiple iterations and very put off from stores that do not sell merchandise consistent with the marketed iteration but try to lump all merchandise for the franchise together as one sales opportunity. The frustration would be far stronger for fans in such an immersive experience as a town or theme park designed to pay homage to the franchise particularly as expectations from fans would already be high for a project of this scale.