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Can Viral Resistance Be Engineered in Humans?

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Jamila Jul 27, 2020

[1]Saha, Shreya, and Kristiina Mäkinen. "Insights into the Functions of eIF4E-Biding Motif of VPg in Potato Virus A Infection." Viruses, 12.2, 2020, pp. 197.

[2]Ruffel, Sandrine, et al. "A natural recessive resistance gene against potato virus Y in pepper corresponds to the eukaryotic initiation factor 4E (eIF4E)." The Plant Journal, 32.6, 2002, pp. 1067-1075.

[3]Montero, Hilda, Rebeca García-Román, and Silvia I. Mora. "eIF4E as a control target for viruses." Viruses, 7.2, 2015, pp. 739-750.

[4]Lellis, Andrew D., et al. "Loss-of-susceptibility mutants of Arabidopsis thaliana reveal an essential role for eIF (iso) 4E during potyvirus infection." Current Biology, 12.12, 2002, pp. 1046-1051.

Creative contributions

Synthetic Genome Recoding

Darko Savic
Darko Savic Aug 04, 2020
Darko Savic
Darko Savic7 months ago
I wonder how long it would take for the first virus to appear for the recoded organism
Subash Chapagain
Subash Chapagain5 months ago
I think laboratory versions are already there. CpG recoding is indeed a brilliant approach. If all hell doesn't break lose for me, this is going to be my PhD research topic, possibly starting in 2021.
Jamila 7 months ago
This is great!!

CRISPPR/Cas9 editing of host cells for viral resistance

Subash Chapagain
Subash Chapagain Sep 14, 2020

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