Facebook PixelCan we develop a cellular nano-sensing mechanism to specifically detect and target viral markers (NA and proteins) to fight viral infections in vivo?
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Can we develop a cellular nano-sensing mechanism to specifically detect and target viral markers (NA and proteins) to fight viral infections in vivo?

Image credit: https://www.dovepress.com/cr_data/article_fulltext/s56000/56771/img/fig3.jpg

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Subash Chapagain
Subash Chapagain Nov 04, 2020

[1]A. I. Usman, A. A. Aziz, and O. A. Noqta, “Application of green synthesis of gold nanopartciels: a review,” Jurnal Teknologi (Sciences & Engineering), vol. 8, no. 1, pp. 171–182, 2019.

[2]L. Murphy, “Biosensors and bioelectrochemistry,” Current Opinion in Chemical Biology, vol. 10, no. 2, pp. 177–184, 2006.

[3]Wilson GS, Gifford R. Biosensors for real-time in vivo measurements. Biosens Bioelectron. 2005;20(12):2388–2403.

[4]Mastrototaro, J.J., 2000. The MiniMed continuous glucose monitoring system. Diabetes Technol. Ther. 2, S13–S18.

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Creative contributions

A stent-based detector of viruses using Luminescent quantum dots (Qdots)

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J
Juran Feb 17, 2021

[1]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746625/

[2]https://pubs.acs.org/doi/full/10.1021/nl034987p

[3]https://www.cell.com/trends/biotechnology/fulltext/S0167-7799(12)00075-3

[4]https://www.semanticscholar.org/paper/A-stent-based-in-vivo-bio-sensing-system-for-Jang-Na/4f6980cc2c629629b7df11b6d8b6bb8afd18b793

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Subash Chapagain
Subash Chapagain9 days ago
Thanks for this input, Juran.

This looks like one viable option. Stents could work like you said if we could develop from the already existing ones to conjugate detection systems (primarily antibody-antigen kind of interactions). The immunosandwich is one technique that I have routinely used in lab experiments, and if we could modify the same technique to use in vivo for real-time monitoring, that would be great. However, these detection systems (at least in the lab) need secondary reagents/washes/buffers and dyes for detection by the detector system (note that usually, it is the spectroscopic features of the sample being analyzed); as well as most of this systems are exhaustive. Hence, while using stents as the platforms for such detection in vivo, I think first we need to figure out ways to do so without any toxic dyes (or develop dyes/buffers/reagents that are absolutely biocompatible).

From your proposed concept, the future direction for this approach would be to investigate if there are any existing mechanisms to make these Qdots durable and consistent over a larger time frame. Also, the signal decay ( given that most of the detection is an electrochemical one, which dissipates with time) poses another difficulty in monitoring- meaning that the system must have an instantaneously transmissible output system that can be monitored in real-time. This is particularly where the idea of prosthetic nanodevices as you mentioned in your session could come in handy.



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