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Can we differentiate between beneficial and detrimental senescent cells?

Image credit: https://www.nature.com/articles/s41570-019-0108-0?platform=oscar&draft=collection

Shubhankar Kulkarni
Shubhankar Kulkarni Aug 04, 2020

[1]Muñoz-Espín D, Cañamero M, Maraver A, Gómez-López G, Contreras J, Murillo-Cuesta S, et al. Programmed Cell Senescence during Mammalian Embryonic Development. Cell [Internet]. 2013 Nov;155(5):1104–18. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0092867413012956

[2]Storer M, Mas A, Robert-Moreno A, Pecoraro M, Ortells MC, Di Giacomo V, et al. Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning. Cell [Internet]. 2013 Nov;155(5):1119–30. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0092867413013597

[3]Helman A, Klochendler A, Azazmeh N, Gabai Y, Horwitz E, Anzi S, et al. p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion. Nat Med [Internet]. 2016 Apr 7;22(4):412–20. Available from: http://www.nature.com/articles/nm.4054

[4]Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, et al. An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA. Dev Cell [Internet]. 2014 Dec;31(6):722–33. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1534580714007291

[5]Ritschka B, Storer M, Mas A, Heinzmann F, Ortells MC, Morton JP, et al. The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration. Genes Dev [Internet]. 2017 Jan 15;31(2):172–83. Available from: http://genesdev.cshlp.org/lookup/doi/10.1101/gad.290635.116

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Could be both?

Jamila Aug 10, 2020

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