ByApoorva Kulkarni
How can we overcome the problem of resistance of the senescent cells to senolytics?
5 months ago
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Brainstorming session
Antonio Carusillo Oct 12, 2020
Subash Chapagain Nov 23, 2020
Can we exploit telomere transfer to rejuvenate certain cell types?
Image credit: https://valelab4.ucsf.edu/external/images/res-tcell_signalling/ArtificalTcell3.jpg
[1]Intercellular telomere transfer extends T cell lifespan Bruno Vaz, Claudia Vuotto, Salvatore Valvo, Clara D’Ambra, Francesco Maria Esposito, Valerio Chiurchiù, Oliver Devine, Massimo Sanchez, Giovanna Borsellino, Derek Gilroy, Arne N. Akbar, Michael L. Dustin, Michael Karin, Alessio Lanna bioRxiv 2020.10.09.331918; doi: https://doi.org/10.1101/2020.10.09.331918
[2]Gaudino SJ, Kumar P. Cross-Talk Between Antigen Presenting Cells and T Cells Impacts Intestinal Homeostasis, Bacterial Infections, and Tumorigenesis. Front Immunol. 2019;10:360. Published 2019 Mar 6. doi:10.3389/fimmu.2019.00360
[3]Dustin ML. The immunological synapse. Arthritis Res. 2002;4 Suppl 3(Suppl 3):S119-S125. doi:10.1186/ar559
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Creative contributions
Can we hijack the mechanism mid-way and exploit the lipid vesicles?