Could Telomere Length and Lifespan be Enhanced with CRISPR?
Image credit: Thomas Ried/NCI Center for Cancer Research
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Is the problem still unsolved?
Is it concisely described?
Tomás-Loba, Antonia, et al. "Telomerase reverse transcriptase delays aging in cancer-resistant mice." Cell, 135.4, 2008, pp. 609-622.
de Jesus, Bruno Bernardes, et al. "Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer." EMBO molecular medicine, 4.8, 2012, pp. 691-704.
Chiba, Kunitoshi, et al. "Cancer-associated TERT promoter mutations abrogate telomerase silencing." Elife, 4, 2015, pp. e07918.
Lewinska, Anna, et al. "Downregulation of methyltransferase Dnmt2 results in condition‐dependent telomere shortening and senescence or apoptosis in mouse fibroblasts." Journal of cellular physiology, 232.12, 2017, pp. 3714-3726.