Does the "bystander effect" affect the rate of aging?
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Nelson G, Wordsworth J, Wang C, Jurk D, Lawless C, Martin-Ruiz C, et al. A senescent cell bystander effect: senescence-induced senescence. Aging Cell [Internet]. 2012 Apr;11(2):345–9. Available from: http://doi.wiley.com/10.1111/j.1474-9726.2012.00795.x
Xu M, Palmer AK, Ding H, Weivoda MM, Pirtskhalava T, White TA, et al. Targeting senescent cells enhances adipogenesis and metabolic function in old age. Elife [Internet]. 2015 Dec 19;4. Available from: https://elifesciences.org/articles/12997
Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, et al. Naturally occurring p16Ink4a-positive cells shorten healthy lifespan. Nature [Internet]. 2016 Feb 3;530(7589):184–9. Available from: http://www.nature.com/articles/nature16932
Possibly, through a chronic inflammation mediated by IL17
- SASP secreted by senescent cells includes cytokines associated with a TH17 immune response including IL6 and IL1β
- these findings support the connection between IL17 production and senescent cell formation
- is happening due to chronic inflammation mediated by IL-17 signaling
- further supported by the SASP and IL-6 from senescent cells
- which act in a chronic positive-feedback-loop manner with Th17
- whic ll raesults in faster and faster aging with increasing number of senescent cells