A fully automated mouse lab for longitudinal studies. It would be place-and-forget, remotely monitored and operate independently for the full lifespan duration of the mice. The system would manage all the needs such as feeding, cleaning, providing therapy as required by the research.
Such a labs could be placed in enviroments that are dificult to manage (ocean floor, low-radiation deep mines, space, moon, Mars)
Disclaimer: I hate myself for comming up with this idea as well. However, not having such a solution would still result in the same fate for mice, except there would be manual human work involved which would stretch over longer time to achieve the same amount of experiments.