How Do Cholinesterase Inhibitors Repigment Hair?
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- Use other cholinesterase inhibitors like physostigmine/eserine, tacrine, metrifonate, and see whether these other cholinesterase inhibitors can also reverse hair greying in humans!
- In animal models observe how acetylcholine impacts melanogenesis on a cellular level.
Chan, Luke Kar Man, et al. "Re‐pigmentation of hair after prolonged cholinesterase inhibitor therapy in a Chinese population." Australasian Journal of Dermatology (2020).
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Picciotto, Marina R., Michael J. Higley, and Yann S. Mineur. "Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior." Neuron 76.1 (2012): 116-129.
Sharma, Kamlesh. "Cholinesterase inhibitors as Alzheimer's therapeutics." Molecular medicine reports 20.2 (2019): 1479-1487.
Hasse, Sybille, et al. "The M4 muscarinic acetylcholine receptor plays a key role in the control of murine hair follicle cycling and pigmentation." Life sciences 80.24-25 (2007): 2248-2252.