Brainstorming session

How do we reverse the greying of the hair?

Image credit: Wendy / ccsearch

Jamila Aug 28, 2020

[1]Seiberg, M. "Age‐induced hair greying–the multiple effects of oxidative stress." International journal of cosmetic science 35.6 (2013): 532-538.

[2]Kumar, Anagha Bangalore, Huma Shamim, and Umashankar Nagaraju. "Premature graying of hair: review with updates." International journal of trichology 10.5 (2018): 198.

hair aging longevity cosmetic

Creative contributions

Stem cell based therapies for hair regeneration

Subash Chapagain Sep 09, 2020

Jamila 5 months ago

Exosomes/miRNA definitely have a big role in melanin production. In a recent study, researchers found that miRNA secreted by keratinocyte derived exosomes had a role in regulating melanogenesis. Specifically, miR-330-5p was produced by keratinocyte derived exosomes. The exosomes with increased expression of miR-330-5p caused an increase in miR-330-5p in melanocytes which resulted in reduced melanin production. (https://www.sciencedirect.com/science/article/pii/S0923181119300271) On the other hand, you have miR-379 which promotes pigmentation. miR‐379 is highly expressed in alpaca melanocytes which leads to increased melanogenesis and proliferation by targeting the insulin‐like growth factor 1 receptor. (https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.14095) These are just examples of how miRNA can positively or negatively impact pigmentation. 

Hair repigmentation after an anti-cancer therapy

Darko Savic Feb 16, 2021

[1]Rivera N, Boada A, Bielsa MI, Fernández-Figueras MT, Carcereny E, Moran MT, Ferrándiz C. Hair Repigmentation During Immunotherapy Treatment With an Anti-Programmed Cell Death 1 and Anti-Programmed Cell Death Ligand 1 Agent for Lung Cancer. JAMA Dermatol. 2017 Nov 1;153(11):1162-1165. doi: 10.1001/jamadermatol.2017.2106. PMID: 28700789; PMCID: PMC5817444.

Blocking Noradrenaline to Prevent Hair Greying

Jamila Aug 28, 2020

Cholinesterase Inhibitors for Grey Hairs

Jamila Sep 18, 2020

Summary of the articles describing medications associated with gray hair repigmentation

Darko Savic Feb 16, 2021

Add your creative contribution

General comments

Darko Savic14 days ago

ByApoorva Kulkarni

How can we overcome the problem of resistance of the senescent cells to senolytics?

5 months ago

ByShubhankar Kulkarni

How could we completely erase the epigenetic marks during cellular reprogramming?

7 months ago

ByShubhankar Kulkarni

Treatment for Age-related Macular Degeneration

7 months ago

ByDeru Xu

How does sleep time affect aging? How to sleep better?

6 months ago

ByDarko Savic

How can people contribute to humanity's quest for biological immortality?

6 months ago

ByBrett M.

What are some of the most promising natural compounds we can use to slow aging?

3 months ago

ByAntonio Carusillo

Can we exploit the Klotho gene for Ageing therapy?

3 months ago

ByShubhankar Kulkarni

Defining the aging phenotype

7 months ago

How do we reverse the greying of the hair?

Creative contributions

Stem cell based therapies for hair regeneration

Hair repigmentation after an anti-cancer therapy

Blocking Noradrenaline to Prevent Hair Greying

Cholinesterase Inhibitors for Grey Hairs

Summary of the articles describing medications associated with gray hair repigmentation

Add your creative contribution

Sign up or

Guest sign up

General comments

ByApoorva Kulkarni

How can we overcome the problem of resistance of the senescent cells to senolytics?

ByShubhankar Kulkarni

How could we completely erase the epigenetic marks during cellular reprogramming?

ByShubhankar Kulkarni

Treatment for Age-related Macular Degeneration

ByDeru Xu

How does sleep time affect aging? How to sleep better?

ByDarko Savic

How can people contribute to humanity's quest for biological immortality?

ByBrett M.

What are some of the most promising natural compounds we can use to slow aging?

ByAntonio Carusillo

Can we exploit the Klotho gene for Ageing therapy?

ByShubhankar Kulkarni

Defining the aging phenotype

How do we reverse the greying of the hair?

Creative contributions

Stem cell based therapies for hair regeneration

Hair repigmentation after an anti-cancer therapy

Blocking Noradrenaline to Prevent Hair Greying

Cholinesterase Inhibitors for Grey Hairs

Summary of the articles describing medications associated with gray hair repigmentation

Add your creative contribution

Sign up or Login

Guest sign up

General comments

ByApoorva Kulkarni

How can we overcome the problem of resistance of the senescent cells to senolytics?

ByShubhankar Kulkarni

How could we completely erase the epigenetic marks during cellular reprogramming?

ByShubhankar Kulkarni

Treatment for Age-related Macular Degeneration

ByDeru Xu

How does sleep time affect aging? How to sleep better?

ByDarko Savic

How can people contribute to humanity's quest for biological immortality?

ByBrett M.

What are some of the most promising natural compounds we can use to slow aging?

ByAntonio Carusillo

Can we exploit the Klotho gene for Ageing therapy?

ByShubhankar Kulkarni

Defining the aging phenotype

Sign up or