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How do we reverse the greying of the hair?

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Jamila
Jamila Aug 28, 2020

[1]Seiberg, M. "Age‐induced hair greying–the multiple effects of oxidative stress." International journal of cosmetic science 35.6 (2013): 532-538.

[2]Kumar, Anagha Bangalore, Huma Shamim, and Umashankar Nagaraju. "Premature graying of hair: review with updates." International journal of trichology 10.5 (2018): 198.

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Creative contributions

Stem cell based therapies for hair regeneration

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Subash Chapagain
Subash Chapagain Sep 09, 2020
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Jamila
Jamila 5 months ago
Exosomes/miRNA definitely have a big role in melanin production. In a recent study, researchers found that miRNA secreted by keratinocyte derived exosomes had a role in regulating melanogenesis. Specifically, miR-330-5p was produced by keratinocyte derived exosomes. The exosomes with increased expression of miR-330-5p caused an increase in miR-330-5p in melanocytes which resulted in reduced melanin production. (https://www.sciencedirect.com/science/article/pii/S0923181119300271) On the other hand, you have miR-379 which promotes pigmentation. miR‐379 is highly expressed in alpaca melanocytes which leads to increased melanogenesis and proliferation by targeting the insulin‐like growth factor 1 receptor. (https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.14095) These are just examples of how miRNA can positively or negatively impact pigmentation.

Hair repigmentation after an anti-cancer therapy

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Darko Savic
Darko Savic Feb 16, 2021

[1]Rivera N, Boada A, Bielsa MI, Fernández-Figueras MT, Carcereny E, Moran MT, Ferrándiz C. Hair Repigmentation During Immunotherapy Treatment With an Anti-Programmed Cell Death 1 and Anti-Programmed Cell Death Ligand 1 Agent for Lung Cancer. JAMA Dermatol. 2017 Nov 1;153(11):1162-1165. doi: 10.1001/jamadermatol.2017.2106. PMID: 28700789; PMCID: PMC5817444.

Blocking Noradrenaline to Prevent Hair Greying

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Jamila
Jamila Aug 28, 2020

Cholinesterase Inhibitors for Grey Hairs

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Jamila
Jamila Sep 18, 2020

Summary of the articles describing medications associated with gray hair repigmentation

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Darko Savic
Darko Savic Feb 16, 2021

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General comments

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Darko Savic
Darko Savic14 days ago
Here is a good recent review on this topic https://www.karger.com/Article/FullText/504414