Telomere length, which is a marker of cellular aging, is one of the research hotspots that has attracted much attention. Telomere refers to the special curved cap-like structure at the end of the chromosome of eukaryotic cells. It is a nucleus composed of DNA repeats containing TTAGGG and telomere binding protein. Protein complex. Telomere length determines the number of cell divisions and survival period, and is a biological marker of cell aging. Telomere length is regulated by genes and affected by various external factors. Normal human cells divide indirectly, and the length of telomeres will be shortened accordingly. When a certain critical value is reached, the cells are prevented from dividing further, leading to cell senescence and death. Senescence is a gradual process. As the risk of injury or disease increases, Healthy individuals can gradually become unhealthy individuals and eventually die . The length of telomeres can reflect the number of cell divisions, suggesting the relationship between actual age and physiological aging. Researchers believe that telomere length is the regulation of biological aging-related processes, and sleep is one of the physiological processes most affected by aging  There are currently some studies on the potential connection between telomere length and sleep and aging, sleep quality and Sleep rhythm is deeply affected by aging. Initial observations have found that sleep loss such as sleep deprivation (SD), sleep restriction or sleep fragmentation and increased oxidative stress damage, abnormal cellular immunity, stress response, inflammatory response, homeostasis Various pathophysiological processes such as imbalance and unfolded protein response  are related to [4-5]. The above-mentioned mechanisms may be involved in the cell aging process, and studies have confirmed that there is a significant correlation between white blood cell telomere length and cell aging  Sleep disorders are very common in the elderly, such as insomnia, obstructive sleep apnea (OSA) , restless legs syndrome (RLS)  or rapid eye movement sleep behavior disorder (RBD) [9-10] With age, sleep physiology changes, the incidence of sleep disorders and other age-related diseases gradually increases, and the telomere length, a marker of cellular aging, also decreases. Recent cross-sectional studies and case-control studies have shown that telomere length is particularly It is the average white blood cell telomere length (LTL) that is related to reduced sleep time and sleep dysfunction . Therefore, some scholars suggest that white blood cell telomere length should be used as a potential marker for age-related sleep disorders. Recognizing biological markers of aging can not only reflect the degree of aging in the biological process, but also evaluate the risk of age-related diseases .
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