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How is IGF-1 Involved in Longevity?

Image credit: Vitale et al. 2019 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367275/)

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Jamila
Jamila Aug 11, 2020

[1]Nishad, Rajkishor, et al. "Growth hormone and metabolic homeostasis." EMJ Diabet, 6, 2018, pp. 78-87.

[2]Harper, James M., et al. "Genetic modulation of hormone levels and life span in hybrids between laboratory and wild-derived mice." The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 61.10, 2006, pp. 1019-1029.

[3]Van Heemst, Diana. "Insulin, IGF-1 and longevity." Aging and disease, 1.2, 2010, pp. 147.

[4]Paolisso, Giuseppe, et al. "Serum levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in healthy centenarians: relationship with plasma leptin and lipid concentrations, insulin action, and cognitive function." The Journal of Clinical Endocrinology & Metabolism, 82.7, 1997, pp. 2204-2209.

[5]Bonafè, Massimiliano, et al. "Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control." The Journal of Clinical Endocrinology & Metabolism, 88.7, 2003, pp. 3299-3304.

[6]Guevara-Aguirre, Jaime, et al. "Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans." Science translational medicine, 3.70, 2011, pp. 70ra13-70ra13.

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Relationship between IGF-1 and lifespan

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Shubhankar Kulkarni
Shubhankar Kulkarni Aug 12, 2020

IGF-1 Prolong Lifespan

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Mohammad Shazaib
Mohammad Shazaib Sep 12, 2020

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