Idea

Fully autonomous place-and-forget mouse lab

Image credit: Aaron Logan

Dragan Otasevic Oct 05, 2020

habitats

General comments

Martina Pesce3 months ago

I believe the idea is brilliant!
Of course, the sooner we manage to research without animals, the better. Unluckily, I really can't imagine animal-free research to start in less than a couple of decades. 
A couple of extra reasons why I think is a great idea: 1) researcher security: visible animal facilities attract animal activist which, despite they rightly remind us to move on in finding alternatives methods, can be at times damaging for investigators privacy, security and mental health; 2)researcher mental health: it has been shown that animal experimentation practices stress out researchers [1]-[4].
A couple of elements to keep in mind for the implementation of this idea: 1) if you were serious about extra-earth location, it would be worth to a) recalculate the cost-benefit of producing such faculties (any technical expert who has an opinion on this?) and b) considering that animals are living beings, you do want someone close by to intervene in case of technical malfunctioning; 2) as Shubhankar Kulkarni also mentioned, human handling is a great resource, for example, to avoid the animal loneliness and consequent stress in periods when the animal must be alone (post surgeries periods, implants installation), so maybe some warm human smelling puppet could trick them (or not).


[1] M. R. LaFollette, M. C. Riley, S. Cloutier, C. M. Brady, M. E. O’Haire, and B. N. Gaskill, “Laboratory Animal Welfare Meets Human Welfare: A Cross-Sectional Study of Professional Quality of Life, Including Compassion Fatigue in Laboratory Animal Personnel,” Front. Vet. Sci., 2020.
[2] P. Bennett and V. Rohlf, “Perpetration-induced Traumatic Stress in Persons Who Euthanize Nonhuman Animals in Surgeries , Animal Shelters , and Laboratories,” Soc. Anim., 2005.
[3] R. L. Scotney, D. McLaughlin, and H. L. Keates, “A systematic review of the effects of euthanasia and occupational stress in personnel working with animals in animal shelters, veterinary clinics, and biomedical research facilities,” J. Am. Vet. Med. Assoc., 2015.
[4] M. Kang, A. R. Han, D. E. Kim, T. Seidle, K. M. Lim, and S. J. Bae, “Mental stress from animal experiments: A survey with Korean researchers,” Toxicol. Res., 2018.

Shubhankar Kulkarni3 months ago

Juran3 months ago

I think the idea is great! Why? 1) The research and development would speed-up drastically, which could be especially useful in pandemic bursts like the COVID-19 one. 2) Clinical trials could become a regular thing in experiments (and not the unfathomable dream), by reducing the costs (specialized automated facilities, no personnel, self-sustaining). Also, 3) by eliminating the human mistake and handling factor, experiments could become more reproducible and more credible. 4) Although people are really creative lately (in silico systems, chips, organoids, organs), there is still no system that can worthly replace mice in clinical trials, especially for complex diseases that affect the whole body. -- I agree that organs on chips or in silico methods seem cool and more humane, but there is still a lot to improve until they become reliable testing systems with all the hormones, physical and chemical imprints of the membranes, channels, tubes, pressures and other that gather the whole inter- and intra- cell/organ/tissue dynamics. For at least a decade, other technologies will not be fully accepted, and that´s why these automated mice facilities could remain important (necessary) and continue to make a change in human health research.

Anja M3 months ago

There is always that question on whether sometimes a full live natural organism is needed to test something, especially if it's so unknown as the surface of some celestial body. However, I remembered two reasons why this may be relieved:
1) Apart from the cruelty part, animal studies are questioned more and more, since their validity in terms of human health and other human-oriented studies often proves not to be enough for more certain conclusions, so this may be an additional reason to put them aside.
2) Organs on chips - This is a news from 2013. where this biologist shows a prototype of a chip where you can plant cells of any organ and then use it for various testing.
https://www.ted.com/talks/geraldine_hamilton_body_parts_on_a_chip#t-787435
Not to mention how this mass-produced makes clinical trials easier, but it can also be custom-made for any individual, and moreover, whole populations and adapted for various testing. I am not sure how it progressed, but I believe it can also succumb to full automation like you suggested. Of course, with proper tuning for a particular need. So maybe something like this can both replace animals and provide some valid tests. If it proves not to be possible, it will probably fail in the same way the validity of animal experiments does to various extents, like I mentioned in 1). Otherwise it can prove beneficial very much, although ultimately, like in the last phase of clinical trials, when the drug is tested on healthy human individuals, we will send someone to remote planets either way. :)

Povilas S3 months ago