Increasing human „shelf life“ by cryogenic freezing
Image credit: https://www.pexels.com/photo/man-wearing-zip-up-jacket-3536513/
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Is the problem still unsolved?
Is it concisely described?
- From the usual hibernation of the animals in cold seasons to Siberian salamanders reviving few years of permafrost, surviving the extremely cold temperatures is not a strange phenomenon.
- More familiar examples are embryos and sperm freezing procedures, which prove that defrosting can be successful in less complex systems of maybe a hundred cells. The longest time after which the frozen embryo resulted in a live birth was 14 years!
- The same was successfully done with a rabbit kidney, which functioned well after being frozen, defrosted, and transplanted back to an animal.
- In 2015, microscopic worms survived being frozen and retained memory.
- In 2016, an MIT graduate successfully froze and defrosted a functional white rabbit brain for the first time.
- The same year, a 26-year-old college student was revived after being drunk and frozen in the snow, having no pulse, heartbeat, or brain activity.
- The first one is that it should be done instantly after death. Every minute without oxygen and nutrients is a bunch of new dead cells and brain damage.
- The second one is the toxicity of a cryoprotectant, that should be completely washed away before “rising from the dead”.
- The third one is an organism's tolerance to a change. If exposure to sun hearts our skin, what damage would arise from a century on -196 degrees Celsius or an uneven cooling-warming of the body?!
- Looked from the other perspective, how is it morally and legally different from euthanasia?
- Also, what happens with the person´s legal profile when it gets frozen? Are you considered dead or “at sleep”?
Cryogenic freezing with amniotic fluid
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Vitrification, and using the nanotechnological solution for minimum damage during revival/thawing back
Fahy GM, Saur J, Williams RJ. Physical problems with the vitrification of large biological systems. Cryobiology. 1990 Oct;27(5):492-510. doi: 10.1016/0011-2240(90)90038-6. PMID: 2249453.
Manuchehrabadi, N., Gao, Z., Zhang, J., Ring, H. L., Shao, Q., Liu, F., McDermott, M., Fok, A., Rabin, Y., Brockbank, K. G. M., Garwood, M., Haynes, C. L., & Bischof, J. C. (2017). Improved tissue cryopreservation using inductive heating of magnetic nanoparticles. Science Translational Medicine, 9(379), eaah4586. https://doi.org/10.1126/scitranslmed.aah4586