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Microcirculation for a better longevity

Image credit: "Retinal Blood Vessels" by BWJones is licensed under CC BY-NC-ND 2.0

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Tarik Regad
Tarik Regad Nov 27, 2020
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Does a better microcirculation promote a long and healthy life?

Microcirculation is a network of blood vessels that provide tissues and organs with essential nutrients and oxygen for their maintenance, activities, and survival, while also cleansing the body’s waste products. Therefore, a better microcirculation is key for a longer and healthier life, and its impairment can lead to premature deaths . This statement is supported by several studies that identified a link between longevity and microcirculation by studying the physiological particularities of nonagenarians and centenarians in different areas and countries on our planet . They found that the most shared characteristic of these limited groups of age is associated with an improved microcirculation that depended on lifestyles, such as physical activity, socioeconomic status, and qualitative food nutrients.

Do you think that other factors may play a role in promoting better microcirculation, and consequently a longer life?

[1]J. P. R. Moore, A. Dyson, M. Singer, J. Fraser, Microcirculatory dysfunction and resuscitation: why, when, and how, BJA: British Journal of Anaesthesia, Volume 115, Issue 3, September 2015, Pages 366–375, https://doi.org/10.1093/bja/aev163

[2]LeBlanc, Amanda J., and James B. Hoying. "Adaptation of the coronary microcirculation in aging." Microcirculation 23.2 (2016): 157-167.

[3]Rizzoni, Damiano, et al. "Vascular aging and disease of the small vessels." High Blood Pressure & Cardiovascular Prevention (2019): 1-7.

[4]Daniels, Lori B., et al. "Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity." Journal of Cardiovascular Medicine 21.2 (2020): 89-98.

[5]Pizza, Vincenzo, et al. "Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO)." Medicina 56.5 (2020): 218.

[6]Willcox, Bradley J., et al. "Siblings of Okinawan centenarians share lifelong mortality advantages." The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 61.4 (2006): 345-354.

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Creative contributions

Adrenomedullin levels and yoga

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Jamila
Jamila Dec 02, 2020
Low levels of adrenomedullin (ADM) is an indication of healthy microcirculation. Those with heart failure have very high ADM levels, and centenarians have low ADM levels in their bodies. Furthermore, higher levels of ADM have been reported in aged human brains compared to younger brains.
So I wondered what could change the ADM levels in the human body. In a study, yoga + mindfulness was able to significantly lower levels of ADM (p < .001) and reduce stress, depression, and sleep problems in adults.

[1]Voors, Adriaan A., et al. "Adrenomedullin in heart failure: pathophysiology and therapeutic application." European journal of heart failure 21.2 (2019): 163-171.

[2]Cabiati, Manuela, et al. "Evaluation of transcriptional levels of the natriuretic peptides, endothelin-1, adrenomedullin, their receptors and long non-coding RNAs in rat cardiac tissue as cardiovascular biomarkers of aging." Peptides 123 (2020): 170173.

[3]Larrayoz, Ignacio M., et al. "Adrenomedullin contributes to age-related memory loss in mice and is elevated in aging human brains." Frontiers in molecular neuroscience 10 (2017): 384.

[4]Daukantaitė, Daiva, et al. "Five-week yin yoga-based interventions decreased plasma adrenomedullin and increased psychological health in stressed adults: A randomized controlled trial." PloS one 13.7 (2018): e0200518.

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