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The role of neurovascular health in aging

Image credit: https://www.nature.com/articles/nrneurol.2017.188?WT.feed_name=subjects_neurodegenerative-diseases

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AP
Andrew Pan Nov 29, 2020

[1]Sweeney, M. D., Kisler, K., Montagne, A., Toga, A. W. & Zlokovic, B. V. The role of brain vasculature in neurodegenerative disorders. Nat. Neurosci.21, 1318–1331 (2018).

[2]Sweeney, M. D., Sagare, A. P. & Zlokovic, B. V. Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. Nat. Rev. Neurol.14, 133–150 (2018).

[3]Luissint, A. C., Artus, C., Glacial, F., Ganeshamoorthy, K. & Couraud, P. O. Tight junctions at the blood brain barrier: Physiological architecture and disease-associated dysregulation. Fluids Barriers CNS9, 1–12 (2012).

[4]Sharif, Y. et al.Blood brain barrier: A review of its anatomy and physiology in health and disease. Clin. Anat.31, 812–823 (2018).

[5]Abbott, N. J. Astrocyte – endothelial interactions and blood – brain barrier permeability *. 629–638 (2002).

[6]Cho, C. F. et al.Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents. Nat. Commun.8, (2017).

[7]Armulik, A. et al.Pericytes regulate the blood-brain barrier. Nature468, 557–561 (2010).

[8]Nation, D. A. et al.Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nat. Med.25, 270–276 (2019).

[9]Katsimpardi, L. et al.Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors. Science (80-. ).344, 630–635 (2014).

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Creative contributions

Whether GDF11 helps in rejuvenation is debated

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Shubhankar Kulkarni
Shubhankar Kulkarni Dec 01, 2020

[1]Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, et al. Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors. Science (80- ) [Internet]. 2014 May 9;344(6184):630–4. Available from: https://www.sciencemag.org/lookup/doi/10.1126/science.1251141

[2]Sinha M, Jang YC, Oh J, Khong D, Wu EY, Manohar R, et al. Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle. Science (80- ) [Internet]. 2014 May 9;344(6184):649–52. Available from: https://www.sciencemag.org/lookup/doi/10.1126/science.1251152

[3]Loffredo FS, Steinhauser ML, Jay SM, Gannon J, Pancoast JR, Yalamanchi P, et al. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell [Internet]. 2013 May 9;153(4):828–39. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23663781

[4]Trendelenburg A, Meyer A, Jacobi C, Feige JN, Glass DJ. TAK-1/p38/nNFκB signaling inhibits myoblast differentiation by increasing levels of Activin A. Skelet Muscle [Internet]. 2012;2(1):3. Available from: http://skeletalmusclejournal.biomedcentral.com/articles/10.1186/2044-5040-2-3

[5]Grens K. Studies Conflict on Regenerative Molecule. The Scientist [Internet]. 2015; Available from: https://www.the-scientist.com/daily-news/studies-conflict-on-regenerative-molecule-35447

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