What is the lethal threshold for molecular damage in humans?

[1]Blagosklonny M V. Aging: ROS or TOR. Cell Cycle [Internet]. 2008 Nov 5;7(21):3344–54. Available from: http://www.tandfonline.com/doi/abs/10.4161/cc.7.21.6965

[2]Khrapko K, Kraytsberg Y, de Grey AD, Vijg J, Schon EA. Does premature aging of the mtDNA mutator mouse prove that mtDNA mutations are involved in natural aging? Aging Cell [Internet]. 2006 Jun;5(3):279–82. Available from: http://doi.wiley.com/10.1111/j.1474-9726.2006.00209.x

[3]Vermulst M, Bielas JH, Kujoth GC, Ladiges WC, Rabinovitch PS, Prolla TA, et al. Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet [Internet]. 2007 Apr 4;39(4):540–3. Available from: http://www.nature.com/articles/ng1988

[4]Wakayama T, Yanagimachi R. Mouse cloning with nucleus donor cells of different age and type. Mol Reprod Dev [Internet]. 2001 Apr 1;58(4):376–83. Available from: https://onlinelibrary.wiley.com/doi/10.1002/1098-2795(20010401)58:4%3C376::AID-MRD4%3E3.0.CO;2-L

[5]Van Remmen H, Ikeno Y, Hamilton M, Pahlavani M, Wolf N, Thorpe SR, et al. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics [Internet]. 2003 Dec 16;16(1):29–37. Available from: https://www.physiology.org/doi/10.1152/physiolgenomics.00122.2003

[6]Lanza RP. Extension of Cell Life-Span and Telomere Length in Animals Cloned from Senescent Somatic Cells. Science (80- ) [Internet]. 2000 Apr 28;288(5466):665–9. Available from: https://www.sciencemag.org/lookup/doi/10.1126/science.288.5466.665