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What is the lethal threshold for molecular damage in humans?

Image credit: Krysko 2011 https://www.cell.com/trends/immunology/fulltext/S1471-4906(11)00014-7

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Shubhankar Kulkarni
Shubhankar Kulkarni Aug 19, 2020

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[3]Vermulst M, Bielas JH, Kujoth GC, Ladiges WC, Rabinovitch PS, Prolla TA, et al. Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet [Internet]. 2007 Apr 4;39(4):540–3. Available from: http://www.nature.com/articles/ng1988

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[5]Van Remmen H, Ikeno Y, Hamilton M, Pahlavani M, Wolf N, Thorpe SR, et al. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics [Internet]. 2003 Dec 16;16(1):29–37. Available from: https://www.physiology.org/doi/10.1152/physiolgenomics.00122.2003

[6]Lanza RP. Extension of Cell Life-Span and Telomere Length in Animals Cloned from Senescent Somatic Cells. Science (80- ) [Internet]. 2000 Apr 28;288(5466):665–9. Available from: https://www.sciencemag.org/lookup/doi/10.1126/science.288.5466.665

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Change as a sign of reaching the threshold

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