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What mechanisms are responsible for telomere shortening in non-dividing cells?

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Darko Savic
Darko Savic Jul 26, 2020
longevitybiochemistry
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Re-induction of cell cycle and oxidative stress

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Shubhankar Kulkarni
Shubhankar Kulkarni Jul 28, 2020
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Aohona Datta7 months ago
The study mentioned in point [1] reports an aging-associated increase in TERT protein levels in cytoplasmic and membrane-bound fractions of murine neocortex. This kind of spatial TERT protein distribution (lowest levels found in the DNA-bound fraction) has been reported in this study: https://sciencematters.io/articles/201604000008. An unidentified embryo-specific DNA-bound telomerase inhibitor may have a role in the regulation of telomerase activity in the developed cortex. The mechanism that governs TERT protein distribution is worth exploring. Reference: Eitan, Erez, et al. “Dissociation between Telomerase Activity and Expression during Mice Cortical Development Due to a DNA-Bound Telomerase Inhibitor.” Matters Select, 2016, doi:10.19185/matters.201604000008.

Telomeres deprotection and shortening in post mitotic cells : a puzzle yet to be solved

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Antonio Carusillo
Antonio Carusillo Sep 08, 2020

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