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Why people taking same dose of Rapamycin have different blood Rapamycin concentrations?

Image credit: https://www.cellsignal.com/products/activators-inhibitors/rapamycin/9904

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Shubhankar Kulkarni
Shubhankar Kulkarni Aug 05, 2020

[1]Blagosklonny M V. Rapamycin for longevity: opinion article. Aging (Albany NY) [Internet]. 2019 Oct 4;11(19):8048–67. Available from: http://www.aging-us.com/article/102355/text

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Creative contributions

Certain disorders can impact the rapamycin concentration

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Juran Dec 12, 2020

[1]Stenton, S. B., Partovi, N., & Ensom, M. H. H. (2005). Sirolimus. Clinical Pharmacokinetics, 44(8), 769–786. doi:10.2165/00003088-200544080-00001

[2]https://www.rxlist.com/slideshow_pictures_high_blood_pressure/article.htm

Interactions with other drugs can influence the rapamycin pharmacokinetics

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J
Juran Dec 12, 2020

[1]Stenton, S. B., Partovi, N., & Ensom, M. H. H. (2005). Sirolimus. Clinical Pharmacokinetics, 44(8), 769–786. doi:10.2165/00003088-200544080-00001

[2]https://link.springer.com/article/10.2165%2F00002018-199818040-00002

Differences in rapamycin concentrations caused by the administration types of Rapamune

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Juran Dec 12, 2020

[1]https://www.rxlist.com/rapamune-drug.htm#clinpharm

It matters if your stomache is full or not

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J
Juran Dec 12, 2020

[1]https://www.rxlist.com/rapamune-drug.htm#clinpharm

[2]Stenton, S. B., Partovi, N., & Ensom, M. H. H. (2005). Sirolimus. Clinical Pharmacokinetics, 44(8), 769–786. doi:10.2165/00003088-200544080-00001

Blood concentration of rapamycin depends on blood composition

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J
Juran Dec 12, 2020

[1]https://www.rxlist.com/rapamune-drug.htm#clinpharm

Different concentration-measuring techniques yielding different results

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J
Juran Dec 12, 2020

[1]Stenton, S. B., Partovi, N., & Ensom, M. H. H. (2005). Sirolimus. Clinical Pharmacokinetics, 44(8), 769–786. doi:10.2165/00003088-200544080-00001

[2]MacDonald A, Scarola J, Burke JT, Zimmerman JJ. Clinical pharmacokinetics and therapeutic drug monitoring of sirolimus. Clin Ther. 2000;22 Suppl B:B101-121. doi: 10.1016/s0149-2918(00)89027-x. PMID: 10823378.

[3]Lee EJ, Kim HK, Ahn S, Lee W, Kim HS, Chun S, Min WK. Accuracy evaluation of automated electrochemiluminescence immunoassay for everolimus and sirolimus compared to liquid chromatography-tandem mass spectrometry. J Clin Lab Anal. 2019 Sep;33(7):e22941. doi: 10.1002/jcla.22941. Epub 2019 Jun 14. PMID: 31197901; PMCID: PMC6757180

[4]https://www.sciencedirect.com/science/article/abs/pii/S0009912009002768

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General comments

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Darko Savic
Darko Savic7 months ago
I would imagine that this is the case with every substance we consume. I look at the human body as one large bioreactor with countless simultaneous chemical reactions continuously taking place since the zygote stage. Even though development follows a "recipe", the product is somewhat unique because it came from so many variables. Everyone is a differently built bioreactor that came from roughly the same plan but made by different crews in different environments :)