Facebook PixelWith respect to longevity, is it better to "go hungry" or "go running"?
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With respect to longevity, is it better to "go hungry" or "go running"?

Image credit: https://www.pexels.com/photo/vegetable-salad-on-white-ceramic-plate-1211887/; https://www.pexels.com/photo/active-adult-athlete-body-416778/

jnikola Dec 14, 2020
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The question:

Is caloric restriction better than burning the calories?

Reading the article from far 2008 , I found some interesting facts:
  • when fed equally, rats who exercised, on average, lived longer than those who didn't
  • the max lifespan of exercising rats was not higher than the max lifespan of non-exercising ones
  • rats that eat normally and exercise live shorter than rats that eat less and do not exercise
  • mice that eat more have higher insulin levels, even if they exercise
  • mice that eat a lot have the highest IGF-1 levels, compared to the ones eating less having the lowest
  • caloric restriction changes levels of hormones in the body
  • mice become healthier only if they start caloric restriction earlier
  • restricting diet without fasting increases the lifespan of 20+ species

To sum it up, it means that:
  • exercise can help prevent diseases, which allows you to live your "normal" lifespan
  • although it helps with diseases, exercise does not prolong the "expected" lifespan
  • caloric restriction, without fasting, has a similar effect on diseases like exercise but also prolongs the lifespan if started early

What are your thoughts on this?
In terms of prolonging your healthspan, would you rather eat normally and exercise or eat less and not exercise?
What could be the underlying mechanism of prolonging the human "expected" lifespan? Hormones?
What is the experiment that could specifically target these changes?

[1]American Physiological Society. "When It Comes To Living Longer, It's Better To Go Hungry Than Go Running, Mouse Study Suggests." ScienceDaily. ScienceDaily, 15 May 2008. <www.sciencedaily.com/releases/2008/05/080514064921.htm>


[3]Oliver Hahn, Lisa F. Drews, An Nguyen, Takashi Tatsuta, Lisonia Gkioni, Oliver Hendrich, Qifeng Zhang, Thomas Langer, Scott Pletcher, Michael J. O. Wakelam, Andreas Beyer, Sebastian Grönke, Linda Partridge. A nutritional memory effect counteracts the benefits of dietary restriction in old mice. Nature Metabolism, 2019; DOI: 10.1038/s42255-019-0121-0

[4]Justin Minnerly, Jiuli Zhang, Thomas Parker, Tiffany Kaul, Kailiang Jia. The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation of Caenorhabditis elegans lifespan. PLOS Genetics, 2017; 13 (5): e1006764 DOI: 10.1371/journal.pgen.1006764

Creative contributions

Has anyone tried a combination of calorie restriction and exercise?

Jamila Dec 15, 2020
Nice session!

It seems that exercise and calorie restriction both have their own benefits. I'm just wondering whether combining exercise and calorie restriction would be more beneficial than exercise and calorie restriction independently.

Researchers could compare the lifespan of mice in the following conditions:
  1. No exercise + calorie restriction
  2. Exercise + normal diet
  3. Exercise + calorie restriction
  4. No exercise + normal diet
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Optimal use of both exercises and caloric restriction

Shubhankar Kulkarni
Shubhankar Kulkarni Dec 16, 2020
We know caloric restriction helps extend lifespan. However, exercises do not help extend lifespan.

But exercises help maintain body fitness and, therefore, its functioning. Fitness maintenance postpones or reduces the frequency of age-related diseases and their progression.

In short, caloric restriction enhances lifespan and exercises enhance the healthspan and maintain the lifespan. Certain age-related diseases may shorten the lifespan and regular exercises may avoid that. There exist links between caloric restriction and exercises. For example, exercising may require higher energy input, and hence, the individual may need to consume more calories. An optimum amount of calorie consumption should accompany exercises. The optimum may differ from person to person.

[1]Mobbs CV, Hof PR (eds): Body Composition and Aging. Interdiscipl Top Gerontol. Basel, Karger, 2010, vol 37, pp 157–174. doi: 10.1159/000320000

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